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Glutaraldehyde

About: Glutaraldehyde is a research topic. Over the lifetime, 4818 publications have been published within this topic receiving 153274 citations. The topic is also known as: Glutaric dialdehyde & 1,5-Pentanedial.


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Journal ArticleDOI
TL;DR: It was shown that heat denatured HSA nanoparticles possessed the greatest number of amino groups on their surface, and the particle size depended mainly on the amount of desolvating agent added, but not on the amounts of cross-linker or the kind of cross -linking procedure.

514 citations

Journal ArticleDOI
TL;DR: In this article, a chitosan:glutaraldehyde molar proportion of 1:20 was established for a CHITOSAN:GLUTARaldehyde mixture.

501 citations

Journal ArticleDOI
TL;DR: The procedure is a simple, rapid staining technique suitable for photomicrography and tissue orientation for electron microscopy, and considerable variation was found in methylene blue-azure II staining times for different embedding media.
Abstract: One micron-thick sections of tissues fixed in glutaraldehyde, or in glutaraldehyde followed by osmium tetroxide, and embedded in a variety of plastic resins were stained in a methylene blue-azure II solution at 65 C, then counterstained in 0.05% basic fuchsin in 2.5% ethanol at room temperature (24 C). Considerable variation was found in methylene blue-azure II staining times for different embedding media. Aged Epon-812 required less staining time than freshly polymerized blocks of Epon-812. The procedure is a simple, rapid staining technique suitable for photomicrography and tissue orientation for electron microscopy.

499 citations

Journal ArticleDOI
TL;DR: In this paper, the formation of Schiff bases during crosslinking of dermal sheep collagen (DSC) with glutaraldehyde (GA), their stability and their reactivity towards GA was studied.
Abstract: The formation of Schiff bases during crosslinking of dermal sheep collagen (DSC) with glutaraldehyde (GA), their stability and their reactivity towards GA was studied. All available free amine groups had reacted with GA to form a Schiff base within 5 min after the start of the reaction under the conditions studied (0.5% (w/w) GA). Before crosslinks are formed the hydrolysable Schiff bases initially present were stabilized by further reaction with GA molecules. An increase in shrinkage temperature (Ts) from 56°C for non-crosslinked DSC (N-DSC) to 78°C for GA crosslinked DSC (G-DSC) was achieved after crosslinking for 1 h. From the relationship between the free amine group content and the Ts during crosslinking it was concluded that higher GA concentrations and longer reaction times will result in the introduction of pendant-GA-related molecules rather than crosslinks. After 24 h crosslinking an average uptake of 3 GA molecules per reacted amine group was found. No increase in the tensile strength of the materials was observed after crosslinking, which may be a result of formation of crosslinks within the fibres rather than in between fibres. Aligning of the fibres by applying a pre-strain to the samples and subsequent crosslinking yielded materials with an increased tensile strength.

496 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023260
2022536
2021110
2020104
2019147
2018155