Topic
Glycal
About: Glycal is a research topic. Over the lifetime, 897 publications have been published within this topic receiving 17422 citations.
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TL;DR: In this paper, a protected 6-aminopyridine C-nucleoside intermediate was converted into the N-oxide followed by Ac2O-mediated rearrangement and final deprotection to give 6-acetylamino-2-oxo(1H)-pyridin-3-yl deoxyribonucleosides.
8 citations
8 citations
TL;DR: In this paper, the first general method for N,N -substituted 2-aminoglycals was reported and the synthesis of 2-[( N -acyl- N -alkyl)amino] and 2]-1,5-anhydro-4,6- O -benzylidene-2-deoxy- erythro -hex-1-en-3-uloses by oxidation of glycoside derivatives of N, N -substantituted-2aminosugars using two oxidant systems.
8 citations
TL;DR: Bi(OTf)3 promoted direct and highly stereoselective glycosylation of "disarmed" and "armed" glycals to synthesize 2-deoxyglycosides has been reported.
8 citations
TL;DR: In this paper, the generic name "glycals" was adopted for this class of unsaturated sugars, which are in fact extensively substituted cyclic vinyl ethers and are also encountered as structural motifs in the total syntheses of some complex natural products.
Abstract: Monosaccharides possessing a double bond between C1 and C2 are known under their trivial name as glycals. The name glycals was coined after the product of the first synthesis of 1,2-unsaturated sugar from D-glucose 1 was named D-glucal 4 [1] Consequently, the generic name “glycals” was adopted for this class of unsaturated sugars, which are in fact extensively substituted cyclic vinyl ethers. Such cyclic vinyl ethers are also encountered as structural motifs in the total syntheses of some complex natural products [2].
8 citations