Topic
Glycal
About: Glycal is a research topic. Over the lifetime, 897 publications have been published within this topic receiving 17422 citations.
Papers published on a yearly basis
Papers
More filters
TL;DR: The use of epoxides obtained by dimethyldioxirane epoxidation of 2,3-anhydro-1,3dideoxy-4,5:7,8-di-O-isopropylidene-D-manno-oct-1-enitol as glycosyl donors is described in this article.
6 citations
TL;DR: The C-glycosidic alkene 21, on treatment with tributyltin hydride and a radical initiator, underwent intramolecular radical cyclisation to give the 2-oxabicyclo[3.2] octane derivative 23 which is structurally related to the sesquiterpenoid trichothecenes.
Abstract: The C-glycosidic alkene 21, on treatment with tributyltin hydride and a radical initiator, underwent intramolecular radical cyclisation to give the 2-oxabicyclo[3.2.1]octane derivative 23 which is structurally related to the sesquiterpenoid trichothecenes. The unsaturated acetals 27 and 29, formed using methods encountered in the first part of the work, permitted branch-point substituents to be introduced regio- and stereo-specifically at C-3 and at C-4 (carbohydrate numbering) of compounds of this type. Methods are thus available for the synthesis of pyranoid derivatives bearing several C-substituents.
6 citations
Patent•
25 Mar 1969
TL;DR: In this article, a StEROID ALCOHOL ROH GLYCAL of the formula is used for the treatment of cardiacs and renal diseases.
Abstract: 2-R2,3,4-DI(R1-O-)-3,4-DIHYDRO-2H-PYRAN AND METHODS OF MAKING THE SAME BY REACTING A STEROID ALCOHOL ROH, WITH A GLYCAL OF THE FORMULA -CH2-O-R1 OR -CH(-O-R1)-CH2-O-R2 USEFUL FOR THE TREATMENT OF CARDIAC AND RENAL DISEASES, WHEREIN R IS A STEROID GROUP OF THE 3-HYDROXY-CARDENOLIDE OR 3-HYDROXYBUFADIENOLIDE SERIES, R1 IS ALIPHATIC OR AROMATIC ACYL, AND R2 IS HYDROGEN, METHYL, ETHYL, OR 2-(R-O-),5-(R''-O-),6-R2-5,6-DIHYDRO-2H-PYRAN STEROID GLYCOSIDES OF THE FORMULA
6 citations
TL;DR: In this paper, a free radical chain mechanism was proposed for the reaction of acetobromoglucose with zinc dust in the presence of a N-base (1-methylimidazole, 4-methylpyridine, or triethylamine, pyridine) in ethyl acetate or benzene was efficiently inhibited by 10-30 mol % of 1,4dinitrobenzene, elemental sulfur, or carbon tetrachloride.
6 citations
TL;DR: Three routes to the synthesis of the title compound, a protected, desmethyl derivative of lemonose, from l-rhamnose or its glycal, were investigated based on electrophilic cyclization, epoxidation-ring opening, and deoxygenation of an intermediate that was used in thehesis of the amino sugar callipeltose.
6 citations