Topic
Glycal
About: Glycal is a research topic. Over the lifetime, 897 publications have been published within this topic receiving 17422 citations.
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TL;DR: Shorter and more efficient routes to 6′-des(N-methyl)sannamycin A and its 2′-epi analog 2 have been elaborated with the proven sannamine-type acceptor 10 and the glycosyl donors 5–8 featuring novel protecting patterns.
6 citations
TL;DR: A simple, catalyst-free glycal diazidation protocol enabled by visible light-driven conditions is described, which requires neither acid promoters nor transition-metal catalysts and takes place at ambient temperature within 1-2 hours.
Abstract: The aminated mimetics of 2-keto-3-deoxy-sugar acids such as the anti-influenza clinical drugs oseltamivir (Tamiflu) and zanamivir (Relenza) are important bioactive molecules. Development of synthetic methodologies for accessing such compound collections is highly desirable. Herein, we describe a simple, catalyst-free glycal diazidation protocol enabled by visible light-driven conditions. This new method requires neither acid promoters nor transition-metal catalysts and takes place at ambient temperature within 1-2 hours. Notably, the desired transformations could be promoted by thermal conditions as well, albeit with lower efficacy compared to the light-induced conditions. Different sugar acid-derived glycal templates have been converted into a range of 2,3-diazido carbohydrate analogs by harnessing this mild and scalable approach, leading to the discovery of new antiviral agents.
6 citations
6 citations
6 citations
TL;DR: In this paper, the azidonitration of di-O-acetyl-l-fucal has been shown to be an efficient route to the bacterial aminosugar Nacetyl l-Fucosamine.
6 citations