Topic
Glycal
About: Glycal is a research topic. Over the lifetime, 897 publications have been published within this topic receiving 17422 citations.
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TL;DR: In this article, a novel and highly stereoselective method for the synthesis of allyl C-glycosides bearing C2-C3 unsaturation has been developed using glycal acetate, allyltrimethylsilane and 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) as a neutral activator.
Abstract: A novel and highly stereoselective method for the synthesis of allyl C-glycosides bearing C2-C3 unsaturation has been developed using glycal acetate, allyltrimethylsilane and 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) as a neutral activator.
TL;DR: The reaction of benzyl protected glycal (I) with both aliphatic and aromatic alcohols in the presence of Al(O-Tf)3 proceeds either via addition or via Ferrier rearrangement depending on the reaction temperature as discussed by the authors.
Abstract: The reaction of benzyl protected glycal (I) with both aliphatic and aromatic alcohols in the presence of Al(O-Tf)3 proceeds either via addition or via Ferrier rearrangement depending on the reaction temperature.
Patent•
24 May 2017
TL;DR: In this article, a simple and easy-to-operate glycal preparation method is presented, which is low-cost and environment-friendly, and has market advantages, while yield of glycal prepared by the method is good.
Abstract: The invention belongs to the technical field of chemical engineering and discloses a preparation method of glycal. The method comprises the following steps: (1) adding an organic solvent into a reactor equipped with polyhydroxyaldehyde monosaccharide and a catalyst in an atmosphere of nitrogen, adding a hydroxyl protective agent, carrying out a reflux reaction, and carrying out subsequent processing to obtain a compound a; (2) successively adding ammonium salt and an organic solvent into the compound a under the condition of nitrogen so as to carry out a reaction, and carrying out subsequent processing to obtain a compound b; (3) letting the compound b, substituted hydrazine and a water-removal additive into an organic solvent under the condition of nitrogen so as to carry out a reaction, and carrying out subsequent processing to obtain a compound c; and (4) adding a catalyst and the compound c dissolved in the organic solvent into alkali under the condition of nitrogen, reacting, and carrying out subsequent processing so as to obtain glycal. The preparation method is simple and easy to operate, is low-cost and environment-friendly, and has market advantages. Meanwhile, yield of glycal prepared by the preparation method is good.
TL;DR: In this article, the synthesis of new enantiomerically pure γ-lactams from d -glucal and d -galactal as starting materials is described.
Abstract: Syntheses of new enantiomerically pure γ-lactams 4a , b and δ-lactams 5a , b from d -glucal ( 3a ) and d -galactal ( 3b ) as starting materials are described.