Topic
Glycal
About: Glycal is a research topic. Over the lifetime, 897 publications have been published within this topic receiving 17422 citations.
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TL;DR: In this article, the naphthylsulphenate ester of 2-hydroxytetralone was used to produce 2-deoxy-β-glycosides as models for the aureolic acid antibiotics.
Abstract: Glucals have been reacted with the naphthylsulphenate ester of 2-hydroxytetralone to afford 2-thio-β-glycosides, which are treated with Raney Ni to produce 2-deoxy-β-glycosides as models for the aureolic acid antibiotics.
27 citations
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TL;DR: In this paper, enol-type alkenes, such as 2,3-dimethylbenzodioxin (1), O-tetrabenzyl glycal (3), 1,2-bis(trimethylsilyloxy)cycloalkenes (9) were transformed in excellent yields to their labile epoxides by dimethyldioxirane (as acetone solution).
27 citations
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27 citations
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TL;DR: A methodology allowing the synthesis alpha-CF(2)-mannosides, based on the addition of a difluoroenoxysilane to a glycal followed by a dihydroxylation reaction, is described, which converts into two pseudoglycopeptides which may act as E- and P-selectin inhibitors.
Abstract: A methodology allowing the synthesis alpha-CF(2)-mannosides, based on the addition of a difluoroenoxysilane to a glycal followed by a dihydroxylation reaction, is described. The resulting 2,2-difluoro-2-mannosylacetate is converted into two pseudoglycopeptides which may act as E- and P-selectin inhibitors.
26 citations
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TL;DR: In this article, 3,4,6-tri-O-benzyl-d-glucal was treated with water and triethylamine in 67% yield, and the putative ring-contracted aldehyde obtained was converted into the showdomycin analogue.
26 citations