Topic
Glycolysis
About: Glycolysis is a research topic. Over the lifetime, 10593 publications have been published within this topic receiving 507460 citations. The topic is also known as: GO:0006096 & glycolysis.
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TL;DR: It is demonstrated that ksr2(-/-) mice are highly efficient in conserving energy, revealing a novel role for KSR2 in AMPK-mediated regulation of energy metabolism.
139 citations
TL;DR: Cancers cells strongly stimulate glycolysis and glutaminolysis for their biosynthesis, which allows cancer cells to burn their host's lipid and protein reserves in order to sustain their own biosynthesis pathways through feedback reactions.
139 citations
TL;DR: The effects and potential clinical impact of 2-DG and 2-FDG as antitumor agents are discussed and the differential mechanisms by which these two glucose analogues produce toxicity in tumor cells growing under anaerobic or aerobic conditions are clarified.
Abstract: The dependence of hypoxic tumor cells on glycolysis as their main means of producing ATP provides a selective target for agents that block this pathway, such as 2-deoxyD -glucose (2-DG) and 2-fluor...
138 citations
TL;DR: The findings suggest that the females have a significantly lower overall capacity for aerobic oxidation and for anaerobic glycolysis than the males and the females has a greater capacity for beta-oxidation relative to the capacity of the citric acid cycle.
138 citations
TL;DR: Mitochondrial Akt-PDK1 signaling correlates with unfavorable prognostic markers and shorter survival in glioma patients and may provide an "actionable" therapeutic target in cancer.
138 citations