Topic
Grading (tumors)
About: Grading (tumors) is a research topic. Over the lifetime, 5144 publications have been published within this topic receiving 144067 citations. The topic is also known as: grading & Neoplasm Grading.
Papers published on a yearly basis
Papers
More filters
TL;DR: The results demonstrate that this method for histological grading provides important prognostic information and, if the grading protocol is followed consistently, reproducible results can be obtained.
Abstract: Morphological assessment of the degree of differentiation has been shown in numerous studies to provide useful prognostic information in breast cancer, but until recently histological grading has not been accepted as a routine procedure, mainly because of perceived problems with reproducibility and consistency. In the Nottingham/Tenovus Primary Breast Cancer Study the most commonly used method, described by Bloom & Richardson, has been modified in order to make the criteria more objective. The revised technique involves semiquantitative evaluation of three morphological features--the percentage of tubule formation, the degree of nuclear pleomorphism and an accurate mitotic count using a defined field area. A numerical scoring system is used and the overall grade is derived from a summation of individual scores for the three variables: three grades of differentiation are used. Since 1973, over 2200 patients with primary operable breast cancer have been entered into a study of multiple prognostic factors. Histological grade, assessed in 1831 patients, shows a very strong correlation with prognosis; patients with grade I tumours have a significantly better survival than those with grade II and III tumours (P less than 0.0001). These results demonstrate that this method for histological grading provides important prognostic information and, if the grading protocol is followed consistently, reproducible results can be obtained. Histological grade forms part of the multifactorial Nottingham prognostic index, together with tumour size and lymph node stage, which is used to stratify individual patients for appropriate therapy.
5,575 citations
TL;DR: There are no systems for grading necroinflammatory activity or for staging fibrosis as exist for various other forms of chronic liver disease and this study proposes a grading and staging system that reflects the unique histological features of nonalcoholic steatohepatitis.
3,553 citations
TL;DR: This is a selection of photographs from around the world taken in the period of May 21 to 29, 1997, which were taken at the request of the then-president of the United States, George W. Bush.
Abstract: ImagesFigs. 19-24Figs. 7-12Figs. 1-6Figs. 13-18Figs. 33-36Figs. 25-29
2,943 citations
Indiana University1, University Health Network2, University Hospital Bonn3, Radboud University Nijmegen4, Cleveland Clinic5, New York University6, Jean Monnet University7, University of Chicago8, University of Queensland9, Erasmus University Rotterdam10, University of California, San Francisco11, Aichi Medical University12, University Hospital of Wales13, Cambridge University Hospitals NHS Foundation Trust14, Baylor College of Medicine15, Wayne State University16, Medical College of Wisconsin17
TL;DR: This manuscript summarizes the proceedings of the ISUP consensus meeting for grading of prostatic carcinoma held in September 2019, in Nice, France, where topics brought to consensus included approaches to reporting of Gleason patterns 4 and 5 quantities, and minor/tertiary patterns.
Abstract: Five years after the last prostatic carcinoma grading consensus conference of the International Society of Urological Pathology (ISUP), accrual of new data and modification of clinical practice require an update of current pathologic grading guidelines. This manuscript summarizes the proceedings of the ISUP consensus meeting for grading of prostatic carcinoma held in September 2019, in Nice, France. Topics brought to consensus included the following: (1) approaches to reporting of Gleason patterns 4 and 5 quantities, and minor/tertiary patterns, (2) an agreement to report the presence of invasive cribriform carcinoma, (3) an agreement to incorporate intraductal carcinoma into grading, and (4) individual versus aggregate grading of systematic and multiparametric magnetic resonance imaging-targeted biopsies. Finally, developments in the field of artificial intelligence in the grading of prostatic carcinoma and future research perspectives were discussed.
2,636 citations
TL;DR: Recombinant human alpha-interferon in patients with chronic nonA-nonB hepatitis and factors predictive of response to interferon alpha therapy in HCV infection are studied.
2,516 citations