Topic
Growth factor receptor inhibitor
About: Growth factor receptor inhibitor is a research topic. Over the lifetime, 4730 publications have been published within this topic receiving 297500 citations.
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TL;DR: The induced expression of the heparan sulfate co-receptor (syndecan-1) may provide a mechanism to restrict FGF action and modulate cell-matrix interactions to maintain co-ordinated growth of cells during organ formation.
123 citations
TL;DR: The usefulness of dominant-negative mutants of the PDGF receptor are demonstrated for the evaluation of the role of the receptor in tumorigenesis and the ability of cells expressing the truncated receptor to grow as xenografts in nude mice was impaired.
123 citations
TL;DR: This article focuses on illustrating the relationship between growth factor signaling and antiestrogen failure in the authors' in-house tumor models of breast cancer and describing how it is now beginning to successfully target growth factor activity to improve the effects of antiestrogens drugs and to block aggressive disease progression.
Abstract: An increasing body of evidence demonstrates that growth factor networks are highly interactive with estrogen receptor signaling in the control of breast cancer growth. As such, tumor responses to antiestrogens are likely to be a composite of the estrogen receptor and growth factor-inhibitory activity of these agents, with alterations/aberrations in growth factor signaling providing a mechanism for the development of antiestrogen resistance. In this light, the current article focuses on illustrating the relationship between growth factor signaling and antiestrogen failure in our in-house tumor models of breast cancer and describing how we are now beginning to successfully target growth factor activity to improve the effects of antiestrogen drugs and to block aggressive disease progression.
123 citations
TL;DR: The partial purification of a T47D factor is described and it is shown that it has properties similar to plateletderived growth factor (PDGF), which acts on mesenchymal cells and suggests a basis for the intense stromal reaction seen in human breast cancers.
Abstract: The breast cancer cell line T47D produces factors which show mitogenic activity for 3T3 cells. Here we describe the partial purification of one of these factors and show that it has properties similar to platelet-derived growth factor (PDGF). The T47D factor is a heat-stable hydrophobic protein with a molecular weight of around 30,000, which inhibits the binding of 125I-EGF in a temperature-dependent manner. This 30 kd protein does not act synergistically with PDGF or fibroblast-derived growth factor (FDGF; also PDGF-like) in stimulating DNA synthesis; moreover, like these two factors, its mitogenic activity can be inhibited by an antiserum raised against human PDGF. A PDGF-like growth factor was also found in the serum-free medium of the breast cancer cell line MDA-MB-157. Since PDGF acts on mesenchymal cells, the production of PDGF-like growth factors by breast cancer cells suggests a basis for the intense stromal reaction seen in human breast cancers.
123 citations
TL;DR: A synergistic antiproliferative activity was obtained when chemotherapy was followed by treatment with EGFR antagonists, and was accompanied by potentiation of apoptosis and arrest of the surviving cancer cells in the G(2)/M phases of the cell cycle.
122 citations