Topic
Growth factor receptor inhibitor
About: Growth factor receptor inhibitor is a research topic. Over the lifetime, 4730 publications have been published within this topic receiving 297500 citations.
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TL;DR: The insulin-like growth factors system, and particularly the IGF-1 receptor, has recently become the subject of major interest in the arena of cancer research and its involvement in cancer cell growth and survival makes the system an excellent target as potential adjunct therapy to standard chemotherapy.
98 citations
TL;DR: Morphine-induced phosphorylation of EGFR occurs via ORs, leading to downstream MAPK/ERK, Akt phosphorylated, cell proliferation, and increased invasion.
Abstract: Background
Epidermal growth factor receptor (EGFR) is co-activated by the μ-opioid receptor (MOR), expressed on non-small cell lung cancer (NSCLC) cells and human lung cancer. We hypothesized that clinically used opioid analgesics that are MOR agonists co-activate EGFR, resulting in growth- and survival-promoting signaling.
97 citations
Journal Article•
TL;DR: It is shown that several adult human primary fibroblast cultures from breast and prostate produce HGF/SF, and that MRC-5 HGF expression is inhibited by several known peptide growth factors, including transforming growth factor beta, epidermal growth factor, and transforming growth factors alpha.
Abstract: Hepatocyte growth factor/scatter factor (HGF/SF) is a stromally derived modulator of epithelial cell proliferation and morphology. To better assess the potential role of HGF/SF in tumor progression we sought to identify factors and biological conditions which regulate its expression. We show that several adult human primary fibroblast cultures from breast and prostate produce HGF/SF. HGF expression in the MRC-5 human fetal lung fibroblast cell line is stimulated by conditioned media harvested from human breast tumor cell lines (MCF-7, T47D, and MDA-MB-231). In contrast, both indirect and direct coculture of each of these tumor lines with MRC-5 fibroblasts down-regulates HGF/SF expression. Finally, we show that MRC-5 HGF expression is inhibited by several known peptide growth factors, including transforming growth factor β, epidermal growth factor, and transforming growth factor α.
97 citations
TL;DR: No differences in growth stimulation were observed between the COX-1 andCOX-2 overexpressions in the authors' experiments, and subtle differences between the both cell lines would be possibly apparent by lower expression levels.
97 citations
TL;DR: The elucidation and use of spontaneously occurring mutants in TNF-related ligands and receptors in addition to gene-targeting experiments have begun to clarify the diverse biological effects mediated by this superfamily of cytokines.
97 citations