Topic
GTP-Binding Protein alpha Subunits
About: GTP-Binding Protein alpha Subunits is a research topic. Over the lifetime, 304 publications have been published within this topic receiving 19915 citations.
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TL;DR: A novel functional regulation of a co-activator directly by G protein subunits is shown, which is normally achieved indirectly via one or more intermediates.
65 citations
TL;DR: It is shown that the GABA-BR1 and BR2 subunits form a functional receptor that recognizes the extreme C-termini of the G alpha i and G alpha o proteins when expressed in HEK293 cells, and these findings correspond to data obtained with the mGluR2 receptor, a distant relative of GABA-B proteins.
65 citations
TL;DR: This work evaluated the interaction of receptors with members of the inwardly rectifying potassium (Kir 3) channel family, which also play an important role in neuronal transmission and membrane excitability, and suggested signalling complexes containing GABA-B receptors, G proteins and Kir channels are formed shortly after biosynthesis most likely in the endoplasmic reticulum.
65 citations
TL;DR: The measurements suggest a model in which G proteins and effectors can exist in stable complexes prior to activation and that activation is achieved through changes in intermolecular interactions rather than diffusion and association.
65 citations
TL;DR: A model is proposed in which, following synthesis on soluble ribosomes, myristoylated αz associates randomly and reversibly with membranes; upon association with the PM, αz binds βγ, which promotes its palmitoylation, thus securing it in the proper place for transmitting the hormonal signal.
64 citations