Guar gum

About: Guar gum is a research topic. Over the lifetime, 5611 publications have been published within this topic receiving 105940 citations.

Improved glucose tolerance four hours after taking guar with glucose.

Abstract: To gain some insights about the possible cumulative metabolic effect after a high-fibre meal, 6 subjects took two 80 g oral glucose loads, 4 h apart Addition of 223 g guar to the first load decreased the rise in blood glucose and insulin after the second (guar-free) load by 50% (p<0002) and 31% (p< 002) respectively This corresponded with decreased 3-hydroxybutyrate levels at the start of the glucose tolerance test after guar (by 20%, p<002) When no guar was added to the first glucose load, both 3-hydroxybutyrate and non-esterified fatty acids tended to rise before the second test No significant effect was seen in the responses of the gut hormones, gastric inhibitory peptide and enteroglucagon Spreading the intake of the first 80 g of glucose over the initial 4 h (2 subjects) similarly flattened the glycaemic but increased the insulin response The effect of guar on carbohydrate and fat metabolism, therefore, lasts at least 4 h and may result in improved carbohydrate tolerance to subsequent guar-free meals

Can We Treat Hydraulic Fracturing Flowback with a Conventional Biological Process? The Case of Guar Gum

Abstract: Hydraulic fracturing of unconventional gas wells utilizes large volumes of water-based fluid to increase formation permeability and, as a result, generates large amounts of wastewater as flowback. This water requires suitable treatment before being reused or discharged into the environment. A principal ingredient of flowback water is guar gum (a gelling agent), which may adversely affect advanced flowback water treatment such as membrane separation. This study demonstrates the potential of an activated sludge mixed liquor to degrade guar under typical flowback conditions (i.e., high concentrations of total dissolved solids (TDS)). Guar was efficiently degraded at a TDS concentration of 1500 mg/L, with more than 90% of the dissolved chemical oxygen demand (CODd) having been removed after 10 h. Increasing the TDS concentration to 45000 mg/L inhibited CODd degradation to 60% removal after 31 h. A high TDS concentration additionally resulted in an increased effluent level of total suspended solids and turbidity; however, these were efficiently reduced using ferric chloride coagulation followed by sedimentation and filtration. Biological reduction of the guar concentration increased the flux of a bench-scale ultrafiltration membrane, demonstrating the potential of the process to treat flowback water prior to membrane separation.

Studies of guar gum compression-coated 5-aminosalicylic acid tablets for colon-specific drug delivery.

Abstract: The aim of this study was to develop colon-specific delivery systems for 5-aminosalicylic acid (5-ASA) using guar gum as a carrier. Core tablets containing 5-ASA were prepared by wet granulation with starch paste and were compression coated with coating formulations containing different quantities of guar gum (300, 200, 150, and 125 mg). In vitro drug release studies were carried out in simulated gastric and intestinal fluids and in pH 6.8 buffer containing rat cecal contents. The application of 175 mg of coating formulation containing 150 mg of guar gum over 5-ASA core tablets resulted in the release of less than 2% drug in simulated gastric and intestinal fluids and about 93% of 5-ASA in pH 6.8 buffer containing rat cecal contents. Differential scanning calorimetric (DSC) studies showed the absence of any interaction between 5-ASA and the excipients on storage at 45°C for 12 weeks. The study confirmed that selective delivery of 5-ASA to the colon can be achieved using guar gum as a carrier in the form o...