Topic
Guar gum
About: Guar gum is a research topic. Over the lifetime, 5611 publications have been published within this topic receiving 105940 citations.
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TL;DR: The modification of guar gum through microwave irradiation by varying the time of irradiation revealed that such modified product has potential applications in colonic drug delivery system.
83 citations
TL;DR: Guar gum and cationic guar gum (CGG) were used to improve lipid bilayer membrane stability and reduce degradation of encapsulated curcumin in this article, and the results indicated that CGG deposited onto the surface of liposomes could stabilize the lipid bilayers better than GG.
83 citations
TL;DR: Strain gauge recordings of the motility of the antrum, duodenum, and jejunum were made in 10 dogs receiving a daily meal of canned food and the increased number of low amplitude contractions when gum was added caused the postprandial motility index to double.
82 citations
TL;DR: Significant potential for binders as tools in significantly reducing the effluent load of fish farms without affecting feed efficiency is demonstrated.
82 citations
TL;DR: A novel formulation consisting of cross-linked microspheres of guar gum has been investigated for colon-targeted delivery of metronidazole, which showed improved drug release in presence of cecal matter obtained after induction when compared to those without induction.
Abstract: Various approaches for colon targeted drug delivery have been studied over the last decade including, pro-drugs, timed-released systems, coating of pH-dependant polymer and the use of polysaccharides. In the present work, a novel formulation consisting of cross-linked microspheres of guar gum has been investigated for colon-targeted delivery of metronidazole. An emulsification method involving the dispersion of aqueous solution of guar gum in castor oil was used to prepare spherical microspheres. Process parameters were analyzed in order to optimize the formulation. Shape and surface morphology of the microspheres were examined using scanning electron microscopy. Placebo microspheres exhibited a smooth surface while the incorporation of drug imparted a slight roughness to the surface texture. Particle size of the microspheres was determined using laser diffraction particle size analyzer. The in vitro drug release studies were performed in simulated gastric fluid for 2 h and intestinal fluid for 3 h, which...
82 citations