Showing papers on "Heck reaction published in 1985"
TL;DR: Complementary approaches to the synthesis of the title compounds were described in this paper, where Metallation of 3,5-di-bromo-2-methoxypyridine (5b) by bromine/lithium exchange gave selectively the 3-lithio intermediate 6 which was trapped with substituted cinnamaldehydes 7, providing allylic alcohols 8 in good yields, and concomitant cyclization occurred on exposure to concentrated hydrobromic acid in hot acetic acid.
10 citations
01 Jan 1985
TL;DR: The organic moiety in organomercurials can be made to add to carbon—carbon double or triple bonds or to substitute olefinic or acetylenic hydrogens thereby greatly expanding the limited number of approaches described in the previous chapter for the alkylation of organomersurials.
Abstract: The organic moiety in organomercurials can be made to add to carbon—carbon double or triple bonds or to substitute olefinic or acetylenic hydrogens thereby greatly expanding the limited number of approaches described in the previous chapter for the alkylation of organomercurials. While few organomercurials will add directly to carbon—carbon multiple bonds, such reactions can be effected via generation of free radical or organopalladium intermediates readily available from organomercurials. These synthetically valuable reactions will be discussed in detail in this chapter.