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Histamine

About: Histamine is a research topic. Over the lifetime, 28227 publications have been published within this topic receiving 752934 citations. The topic is also known as: 2-(1H-imidazol-5-yl)ethanamine & 2-(1H-imidazol-5-yl)ethylamine.


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Journal Article
TL;DR: Gross dissection of brain showed no marked localization of brain histamine and a sensitive and specific fluorometric method for the estimation of histamine in tissues was described.
Abstract: A sensitive and specific fluorometric method for the estimation of histamine in tissues is described. The method involves extraction of histamine into butanol from alkalinized perchloric acid tissue extracts, return to an aqueous phase, and condensation with o -phthalaldehyde to form a highly fluorescent product which is estimated in a spectrofluorometer. Concentrations of histamine as low as 0.005 µg/ml can be assayed. Low levels of histamine (0.2-0.4 µg/g) occur in brain. Gross dissection of brain showed no marked localization of brain histamine.

2,352 citations

Journal ArticleDOI
21 Apr 1972-Nature
TL;DR: H2-receptor antagonist, a new group of drugs, may help to unravel the physiology of histamine and gastrin.
Abstract: H2-receptor antagonist, a new group of drugs, may help to unravel the physiology of histamine and gastrin.

2,135 citations

Journal ArticleDOI
TL;DR: This review highlights what is known about mast cells, basophils, and eosinophils and their roles in disease pathogenesis and central effector cells in allergic inflammation.
Abstract: IgE, mast cells, basophils, and eosinophils are essential components of allergic inflammation. Antigen-specific IgE production, with subsequent fixation of IgE to FceRI receptors on mast cells and basophils, is central to the initiation and propagation of immediate hypersensitivity reactions. Mast cells, basophils, and eosinophils are central effector cells in allergic inflammation, as well as in innate and adaptive immunity. This review highlights what is known about these components and their roles in disease pathogenesis.

1,528 citations

Journal ArticleDOI
TL;DR: Only mast cells in close proximity to nerves were significantly correlated with severity and frequency of abdominal pain/discomfort, and mediator release in proximity to mucosal innervation may contribute to abdominal pain perception in IBS patients.

1,310 citations

Journal ArticleDOI
04 May 1989-Nature
TL;DR: It is shown that cross-linkage of FcεRI on a series of non-transformed murine mast cell lines, or treatment of these cells with calcium ionophores, stimulates increased messenger RNA levels and secretion of a group of lymphokines classically produced by a subset of murine T cell lines (TH2cells).
Abstract: The cross-linkage of high affinity Fc epsilon receptors (Fc epsilon RI) on mast cells and basophils is central to the induction of allergic inflammatory responses. As a result of such cross-linkage, mast cells secrete a variety of preformed biologically active substances, such as histamine, and newly synthesized arachidonic acid metabolites. Here we show that cross-linkage of Fc epsilon RI on a series of nontransformed murine mast cell lines, or treatment of these cells with calcium ionophores, stimulates increased messenger RNA levels and secretion of a group of lymphokines classically produced by a subset of murine T cell lines (TH2 cells). These factors include interleukin-3 (a mast cell growth factor)s interleukin-4 (an IgE 'switch factor'), interleukin-5 (an eosinophil differentiation factor) and interleukin-6 (a factor controlling immunoglobulin secretion). The production of these polypeptide factors by mast cells may have great importance in the induction of allergic and anti-parasite inflammatory responses.

1,155 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023252
2022559
2021231
2020245
2019252
2018252