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Histone methyltransferase

About: Histone methyltransferase is a(n) research topic. Over the lifetime, 7989 publication(s) have been published within this topic receiving 725726 citation(s). The topic is also known as: histone methylase & histone methyltransferases. more


Open accessJournal ArticleDOI: 10.1016/J.CELL.2007.05.009
Artem Barski1, Suresh Cuddapah1, Kairong Cui1, Tae-Young Roh1  +5 moreInstitutions (2)
18 May 2007-Cell
Abstract: Histone modifications are implicated in influencing gene expression. We have generated high-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the insulator binding protein CTCF across the human genome using the Solexa 1G sequencing technology. Typical patterns of histone methylations exhibited at promoters, insulators, enhancers, and transcribed regions are identified. The monomethylations of H3K27, H3K9, H4K20, H3K79, and H2BK5 are all linked to gene activation, whereas trimethylations of H3K27, H3K9, and H3K79 are linked to repression. H2A.Z associates with functional regulatory elements, and CTCF marks boundaries of histone methylation domains. Chromosome banding patterns are correlated with unique patterns of histone modifications. Chromosome breakpoints detected in T cell cancers frequently reside in chromatin regions associated with H3K4 methylations. Our data provide new insights into the function of histone methylation and chromatin organization in genome function. more

Topics: Histone code (75%), Histone H2A (72%), Histone methyltransferase (72%) more

6,053 Citations

Open accessJournal ArticleDOI: 10.1016/S0092-8674(00)81656-6
29 Oct 1999-Cell
Abstract: The establishment of DNA methylation patterns requires de novo methylation that occurs predominantly during early development and gametogenesis in mice. Here we demonstrate that two recently identified DNA methyltransferases, Dnmt3a and Dnmt3b, are essential for de novo methylation and for mouse development. Inactivation of both genes by gene targeting blocks de novo methylation in ES cells and early embryos, but it has no effect on maintenance of imprinted methylation patterns. Dnmt3a and Dnmt3b also exhibit nonoverlapping functions in development, with Dnmt3b specifically required for methylation of centromeric minor satellite repeats. Mutations of human DNMT3B are found in ICF syndrome, a developmental defect characterized by hypomethylation of pericentromeric repeats. Our results indicate that both Dnmt3a and Dnmt3b function as de novo methyltransferases that play important roles in normal development and disease. more

Topics: RNA-Directed DNA Methylation (67%), DNA methylation (64%), Methylation (62%) more

5,304 Citations

Open accessJournal ArticleDOI: 10.1016/J.CELL.2006.02.041
21 Apr 2006-Cell
Abstract: The most highly conserved noncoding elements (HCNEs) in mammalian genomes cluster within regions enriched for genes encoding developmentally important transcription factors (TFs). This suggests that HCNE-rich regions may contain key regulatory controls involved in development. We explored this by examining histone methylation in mouse embryonic stem (ES) cells across 56 large HCNE-rich loci. We identified a specific modification pattern, termed "bivalent domains," consisting of large regions of H3 lysine 27 methylation harboring smaller regions of H3 lysine 4 methylation. Bivalent domains tend to coincide with TF genes expressed at low levels. We propose that bivalent domains silence developmental genes in ES cells while keeping them poised for activation. We also found striking correspondences between genome sequence and histone methylation in ES cells, which become notably weaker in differentiated cells. These results highlight the importance of DNA sequence in defining the initial epigenetic landscape and suggest a novel chromatin-based mechanism for maintaining pluripotency. more

Topics: Bivalent chromatin (71%), DNA methylation (61%), Histone methylation (61%) more

4,800 Citations

Open accessJournal ArticleDOI: 10.1038/CR.2011.22
Andrew J. Bannister1, Tony Kouzarides1Institutions (1)
15 Feb 2011-Cell Research
Abstract: Chromatin is not an inert structure, but rather an instructive DNA scaffold that can respond to external cues to regulate the many uses of DNA. A principle component of chromatin that plays a key role in this regulation is the modification of histones. There is an ever-growing list of these modifications and the complexity of their action is only just beginning to be understood. However, it is clear that histone modifications play fundamental roles in most biological processes that are involved in the manipulation and expression of DNA. Here, we describe the known histone modifications, define where they are found genomically and discuss some of their functional consequences, concentrating mostly on transcription where the majority of characterisation has taken place. more

Topics: Histone code (74%), Epigenomics (65%), Histone-modifying enzymes (65%) more

3,710 Citations

Yang Shi1, Yujiang Shi1Institutions (1)
16 Dec 2005-Cell
Abstract: LSD1, a homolog of nuclear amine oxidases, functions as a histone demethylase and transcriptional co-repressor. LSD1 specifically demethylates histone H3 lysine 4, which is linked to active transcription. Lysine demethylation occurs via an oxidation reaction that generates formaldehyde. Importantly, RNAi inhibition of LSD1 causes an increase in H3 lysine 4 methylation and concomitant de-repression of target genes, suggesting that LSD1 represses transcription via histone demethylation. The results thus identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histone methylases and demethylases. more

3,281 Citations

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Topic's top 5 most impactful authors

C. David Allis

91 papers, 31.9K citations

Gary S. Stein

53 papers, 2.2K citations

Janet L. Stein

52 papers, 2.2K citations

Benjamin A. Garcia

37 papers, 5.4K citations

Yi Zhang

37 papers, 18.3K citations

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