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Human chorionic gonadotropin

About: Human chorionic gonadotropin is a research topic. Over the lifetime, 7183 publications have been published within this topic receiving 185720 citations. The topic is also known as: Ovidrel & Atc Code G03 Ga Gonadotropins.


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Journal ArticleDOI
TL;DR: The total rate of pregnancy loss after implantation, including clinically recognized spontaneous abortions, was 31 percent and most of the 40 women with unrecognized early pregnancy losses had normal fertility, since 95 percent of them subsequently became clinically pregnant within two years.
Abstract: We studied the risk of early loss of pregnancy by collecting daily urine specimens from 221 healthy women who were attempting to conceive. Urinary concentrations of human chorionic gonadotropin (hCG) were measured for a total of 707 menstrual cycles with use of an immunoradiometric assay that is able to detect hCG levels as low as 0.01 ng per milliliter, with virtually 100 percent specificity for hCG in the presence of luteinizing hormone. Our criterion for early pregnancy--an hCG level above 0.025 ng per milliliter on three consecutive days--was determined after we compared the hCG levels in the study group with the levels in a comparable group of 28 women who had undergone sterilization by tubal ligation. We identified 198 pregnancies by an increase in the hCG level near the expected time of implantation. Of these, 22 percent ended before pregnancy was detected clinically. Most of these early pregnancy losses would not have been detectable by the less sensitive assays for hCG used in earlier studies. The total rate of pregnancy loss after implantation, including clinically recognized spontaneous abortions, was 31 percent. Most of the 40 women with unrecognized early pregnancy losses had normal fertility, since 95 percent of them subsequently became clinically pregnant within two years.

1,926 citations

Journal ArticleDOI
TL;DR: A radioimmunoassay which selectively measures HCG in samples containing both human pituitary luteinizing hormone (HLH) and HCG, and the sensitivity of the assay is sufficient for distinguishing HCG from follicular and luteal phase HLH levels.

850 citations

Journal ArticleDOI
TL;DR: The assay is sufficiently sensitive to permit quantitation of normal amounts of luteinizing hormone in 0.1 ml of unconcentrated serum and urine of women near the time of presumed ovulation.
Abstract: Purified human chorionic gonadotropin has been radioiodinated to give an immunologically and biologically active product which possesses high specific activity. With this labeled hormone and an antiserum which is capable of reacting specifically with human luteinizing hormone and human chorionic gonadotropin, a sensitive and specific radioimmunoassay has been developed. Comparable results have been obtained when the content of luteinizing hormone in preparations differing widely in luteinizing and follicle stimulating activity have been estimated by the radioimmunoassay and the ovarian ascorbic acid depletion bio-assay. The assay is sufficiently sensitive to permit quantitation of normal amounts of luteinizing hormone in 0.1 ml of unconcentrated serum and urine. With the use of the assay, peaks in concentration of luteinizing hormone have been found in serum and urine of women near the time of presumed ovulation. (Endocrinology 79: 10, 1966)

756 citations

Journal ArticleDOI
TL;DR: It has been known for some time that human chorionic gonadotropin (HCG) will augment the action of FSH in the ovary and Bates and Schooley (1942) indicated that it might be possible to use it as an assay method.
Abstract: INTRODUCTION There have been in the past numerous attempts to quantitatively assay the follicle stimulating hormone (FSH) of the anterior pituitary. Fevold et al. (1937, 1940) and many others have used the increase in ovarian weight in immature female rats. Evans et al. (1939) have employed an histological assay based upon the production of healthy (nonatretic) follicles with small antra in the ovaries of hypophysectomized female rats. Many other workers use uterine weight as a criterion for the estimation of FSH activity. In hypophysectomized male rats Greep et al. (1940, 1942) have employed the increase in testicular weight, in the absence of hypertrophy of the prostate and seminal vesicles, as a means of determination of FSH. It has been known for some time that human chorionic gonadotropin (HCG) will augment the action of FSH in the ovary. Bates and Schooley (1942) in their excellent article on this subject indicated that it might be possible to use it as an assay method.

694 citations

Journal ArticleDOI
TL;DR: Based on the recent discovery of GnRH multiplicity in fish and the increasing understanding of its functional significance, new GnRH agonists can be designed for more potent, affordable and physiologically-compatible spawning induction therapies.

590 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023157
2022326
2021111
2020137
2019136
2018134