Topic
Human serum albumin
About: Human serum albumin is a research topic. Over the lifetime, 9402 publications have been published within this topic receiving 269029 citations. The topic is also known as: serum albumin & ALB.
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TL;DR: The adsorption of lysozyme and human serum albumin onto hydrogel contact lenses was investigated as a function of lens surface charge and the fact that HSA was not observed on either the anionic or non-ionic charged species demonstrates the effect of charge repulsion.
93 citations
93 citations
TL;DR: It is found that also albumin can participate in the transport of an insulin-enhancing compound forming a mixed species cis-VO(carrier)( 2)(HSA), when the carrier stabilizes in aqueous solution the cis-octahedral form, or the dinuclear compound (VO)(2)(d)HSA, when the carriers forms unstable complexes.
Abstract: The possible biotransformations in the blood serum of four representative insulin-enhancing vanadium compounds, [VO(6-mepic)2], cis-[VO(pic)2(H2O)], [VO(acac)2], and [VO(dhp)2], where 6-mepic, pic, acac, and dhp indicate the deprotonated forms of 6-methylpicolinic and picolinic acids, acetylacetone, and 1,2-dimethyl-3-hydroxy-4(1H)-pyridinone, were examined. In particular, the behavior of the quinary systems formed by the insulin-enhancing species, human serum apo-transferrin (hTf), human serum albumin (HSA), and lactate (lact) or citrate (citr) at physiological pH and conditions was studied. The results indicate that, besides the case in which the ligand is very weak like 6-mepic, the carrier can interact in some form with VO2+ ion until its intake into the cell. In fact with stronger ligands like pic, acac, and dhp, VO2+ is transported not only by transferrin but also as [VO(carrier)2] and as mixed species VO2+−hTF−carrier. There are two ways in which the undissociated form of a bis-chelated complex can...
93 citations
TL;DR: The plasma protein binding studies conducted on four gyrase inhibitors in rat and human plasma exhibited no interspecies difference via ultra filtration method, which proves that both the techniques have their own merits and demerits and should be exploited judiciously as per the requirement.
93 citations
TL;DR: Serum albumin is negatively correlated with increased extracellular fluid volume and the proportion of Vecf to Vtbw is increased in hypoalbuminaemic patients, and multifrequency bioelectrical impedance is able to identify these abnormalities.
Abstract: Aim. To investigate the relationship between serum albumin and extracellular fluid volume, as measured by multifrequency bioelectrical impedance, in stable patients treated by CAPD. Method. Fifty-nine stable CAPD patients were assessed. Serum albumin (bromocresol green) and CRP, age, dialysate to plasma (D/P) creatinine ratio, normalized protein catabolic rate (nPCR), daily urine and peritoneal protein losses, and extracellular fluid volume (Vecf) were measured in each patient. Vecf was calculated as a percentage of actual body weight (Vecf% ABW ), of lean body mass derived from anthropometry (Vecf% LBM ) and of total body water ( Vecf% Vtbw). Comparisons between those with a normal serum albumin (≥37 g/l) and those with a low serum ajbumin (<37 g/l) were made by Mann-Whitney U test. Correlations with serum albumin were sought by Pearson's test. Results. The D/P creatinine ratio, daily peritoneal and urine protein losses, and extracellular fluid volume (Vecf% LBM and Vecf% Vtbw) were all significantly greater in patients with serum albumin <37 g/1 as compared to those ≥37 g/l; P< 0.05. Age, CRP, and nPCR were not different. Serum albumin was negatively correlated with Vecf% LBM, r = - 0.25; P= 0.05, Vecf% Vtbw, r= -0.39; P=0.002, and daily urinary albumin loss, r= -0.25, P=0.06. Conclusion. Hypoalbuminaemia is partly dependent on subclinical overhydration in CAPD patients. Serum albumin is negatively correlated with increased extracellular fluid volume and the proportion of Vecf to Vtbw is increased in hypoalbuminaemic patients. Multifrequency bioelectrical impedance is able to identify these abnormalities.
93 citations