Topic
Human serum albumin
About: Human serum albumin is a research topic. Over the lifetime, 9402 publications have been published within this topic receiving 269029 citations. The topic is also known as: serum albumin & ALB.
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TL;DR: It was proved that the fluorescence quenching of HSA by palmatine is a result of the formation ofPalmatine/HSA complex and the electrostatic interactions play a major role for palmatin-HSA association.
241 citations
TL;DR: The binding of bilirubin to serum albumin has been known for more than fifty years, but the affinity is high and it has not been possible to determine the dissociation constant, since a sensitive method for measuring the very low concentrations of non-bound bilirUBin has not be available.
240 citations
TL;DR: Several crystal forms of serum albumin suitable for three-dimensional structure determination have been grown and two of the crystal forms produced from human and canine albumin include incorporated long-chain fatty acids.
Abstract: Several crystal forms of serum albumin suitable for three-dimensional structure determination have been grown These forms include crystals of recombinant and wild-type human serum albumin, baboon serum albumin, and canine serum albumin The intrinsic limits of X-ray diffraction for these crystals are in the range 028-022 nm Two of the crystal forms produced from human and canine albumin include incorporated long-chain fatty acids Molecular replacement experiments have been successfully conducted on each crystal form using the previously determined atomic coordinates of human serum albumin illustrating the conserved tertiary structure
239 citations
TL;DR: It is shown that more than one mechanism is involved in the interaction of nanoparticles with the brain endothelial cells and the resulting delivery of drugs to the central nervous system through the NHS-PEG-Mal 3400 linker.
239 citations
TL;DR: The sensitivity of surface plasmon resonance techniques to changes in local interfacial refractive index has been exploited to detect immuno-complex formation in two model biochemical systems and binding reactions could be followed with respect to time.
237 citations