Topic
Human serum albumin
About: Human serum albumin is a research topic. Over the lifetime, 9402 publications have been published within this topic receiving 269029 citations. The topic is also known as: serum albumin & ALB.
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TL;DR: A new method for the preparation of porous spherical hydroxyapatite granules is reported and its application towards delivery of macromolecules or protein drugs is discussed utilizing human serum albumin (HSA) as a model protein.
Abstract: A new method for the preparation of porous spherical hydroxyapatite granules is reported. It may be clinically applied towards orthopaedic or maxillofacial surgery as fillers or packing materials, and as biological chromatography supports. Its application towards delivery of macromolecules or protein drugs is discussed utilizing human serum albumin (HSA) as a model protein.
226 citations
TL;DR: It was proved that the fluorescence quenching of HSA by CS is a result of the formation of a CS-HSA complex and synchronous fluorescence spectroscopy data and UV-vis absorbance spectra have suggested that the association between CS and HSA changed the molecular conformation of H SA and the electrostatic interactions play a major role in CS-hSA association.
225 citations
TL;DR: The binding characteristics of the human serum protein beta 2-glycoprotein-I, also called apolipoprotein H, with multilamellar phospholipid vesicles has been studied and it was found thatbeta 2-G-I is not or almost not bound to the "neutral"ospholipids phosphatidylcholine (PC),osphatidylethanolamine (PE) and sphingomyelin (SM).
224 citations
TL;DR: Using monoclonal antibodies against human serum albumin (HSA) to develop an immunoaffinity resin that is effective in the removal of both full-length HSA and many of the HSA fragments present in serum shows markedly better performance than dye-based resins in terms of both the efficiency and specificity of albumin removal.
222 citations
TL;DR: It is shown that HSA can be successfully incorporated into micro spheres and released intact from these microspheres into various buffer systems at 37°C, demonstrating the potential of poly(DL-lactide-co-glycolide) microsphere for continuous delivery of large proteins.
Abstract: Human serum albumin (HSA) was encapsulated in a 50:50 copolymer of DL-lactide/glycolide in the form of microspheres. These microspheres were used as a model formulation to study the feasibility of controlling the release of large proteins over a 20- to 30-day period. We show that HSA can be successfully incorporated into microspheres and released intact from these microspheres into various buffer systems at 37°C. A continuous release of the protein could be achieved in physiological buffers at 37°C over a 20- to 30-day period from microspheres with high protein loadings (11.6%). These results demonstrate the potential of poly(DL-lactide-co-glycolide) microspheres for continuous delivery of large proteins.
221 citations