Showing papers on "Hydrazone published in 1969"
TL;DR: The authors showed that the α-15 N label in the diazonium salt migrates during hydrolysis to the β position to about the extent indicated by a degradative method.
15 citations
TL;DR: The data presented in this paper show that the α-β unsaturated aldehyde forms a stable thiosemicarbazone, suggesting that these more reactive aldehydes play an important role in the formation of these cross-links.
12 citations
TL;DR: In this paper, the partial rearrangement of primeverulose with aqueous ammonia followed by separation of the two disaccharides on a cellulose column was described.
10 citations
TL;DR: In this article, an attempt to cyclize orotaldehyde hydrazone in acidic media failed to succeed, and its acyl derivatives were obtained as sole products, such as uracil-6-acetic hydrazide.
Abstract: Upon treatment with hydrazine hydrate in ethanol, ethyl 5-bromorotate and 5 bromuracil-6-acetate were converted into the corresponding 5-hydrazino esters. An attempt to cyclize orotaldehyde hydrazone in acidic media failed to succeed, and its acyl derivatives were obtained as sole products.Uracil-6 -acetic acid was converted into uracil-6-acetic hydrazide through its esters. The hydrazide was then treated with carbon disulfide in pyridine to obtain 2- (5-uracilmethyl) -1, 3, 4-oxadiazole-5-thion. Uracil-6-acetic hydrazide was also treated with phenyl isothiocyanate in pyridine to form a semicarbazide, which was subsequently converted into 3- (6-uracilmethyl) -4-phenyl-1, 2, 4-triazole-5-thion through alkali treatment. Treatment of the acyl hydrazide with potassium thiocyanate in hydrochloric acid gave a bis- (acyl hydrazide). Similar treatment with potassium cyanate afforded N1- (6-uracilacety1) -semicarbazide, which was then cyclized, upon alkali treatment, into 1H, 2H-dihydropyridazo-C3, [3, 4-d] pyrimidine.
7 citations
TL;DR: Japp-Klingemann synthesis of 2-Carboxy-5-hydroxytryptamine and Pyridazine derivatives is described in this paper, where the latter is cyclized to tetrahydropyridazin derivatives.
6 citations
TL;DR: The relationship between the structures of the compounds and their in vitro and in vivo antimicrobial activity was investigated.
6 citations
Journal Article•
TL;DR: Several new folic acid and aminopterin analogues were synthesized, in which the aliphatic chain binding the pteridine and aromatic nucleus was extended by 1 nitrogen atom, and showed no significant inhibitory effect on HeLa cells grown in tissue culture, or any toxicity for mice in doses up to 100 mg/kg.
Abstract: Several new folic acid and aminopterin analogues were synthesized, in which the aliphatic chain binding the pteridine and aromatic nucleus was extended by 1 nitrogen atom. Condensation of 2-amino-4-hydroxypteridine-6-aldehyde with p-hydrazinobenzoylglutamate gave a hydrazone whose carbon-nitrogen double bond was reduced by sodium borohydride to form 11-azahomofolic acid. 11-Azahomopteroic acid was prepared by the condensation of 2-amino-4-hydroxypteridine-6-aldehyde with p-hydrazinobenzoic acid and subsequent reduction of the hydrazone with sodium borohydride. 11-Azahomoaminopterin and 4-aminoazahomopteroic acid were prepared in the same manner, using 2,4-diaminopteridine-6-aldehyde as the starting compound. The 5,6,7,8-tetrahydro derivatives of azahomofolic acid and azahomoaminopterin were prepared by catalytic hydrogenation of the parent compounds in glacial acetic acid. Azahomopteroic acid and related compounds showed no significant inhibitory effect on HeLa cells grown in tissue culture, or any toxicity for mice in doses up to 100 mg/kg. Azahomoaminopterin, its parent hydrazone, and analogous pteroic acid derivatives exhibited a marked cytostatic effect on HeLa cells and were toxic for mice in doses exceeding 100 mg/kg, whereas 4-aminoazahomopteroic acid and its parent hydrazone showed no toxicity when administered in the same doses. Among the enzymes interconverting folic acid or involving tetrahydrofolate as a coenzyme, thymidylate synthetase was inhibited slightly by azahomoaminopterin and more strongly by its tetrahydro derivative, the inhibition being noncompetitive versus tetrahydrofolate. Folate reductase from mouse liver was inhibited by all the analogues containing an NH2 group in position 4 (azahomoaminopterin and related substances). Azahomofolic acid and its derivatives were ineffective. Other tetrahydrofolate-interconverting enzyme systems and purine biosynthesis were not inhibited by any of the compounds studied.
4 citations
TL;DR: The reaction of malondialdehydedioxim with aromatic diazonium salts or nitrous acid leads to derivatives 5 of cyanoacetaldehyde in a quite simple way as mentioned in this paper.
4 citations
2 citations
TL;DR: The oximes and hydrazones of 2,6-diaryltetrahydro-1-thio-4-pyrones (I) and their sulphones (II) have been prepared and converted into the azines (III), (IV), and (V) as discussed by the authors.
Abstract: The oximes and hydrazones of 2,6-diaryltetrahydro-1-thio-4-pyrones (I) and their sulphones (II) have been prepared and the hydrazones converted into the azines (III), (IV), and (V). From 2,6-di-p-methoxyphenyltetrahydro-1-thio-4-pyrone, we prepared 3,5-dichloro-2,6-di-p-methoxyphenyl-1-thio-4-pyrone and converted it into its 4-thio-analogue, oxime, hydrazone, and phenylhydrazone. The structures of the new compounds have been proved by hydrolysis, acylation, and i.r. and u.v. spectroscopy.
1 citations
TL;DR: The evaluation of a specific gas Chromatographie detector for carbonyl compounds is described, based on the polarographic reduction of the Girard T hydrazone derivative, which was used to monitor the separation of a homologous series of alkanals.