Showing papers on "Hydrazone published in 1987"
114 citations
TL;DR: In this article, various oximes and hydrazones with dinitrogen tetroxide (N 2 O 4 ) at low temperature in acetonitrile gave the corresponding ketones respectively in excellent yields.
66 citations
TL;DR: In this paper, aldehydes and ketones undergo intermolecular cycloaddition to electronegative olefins via azomethine imines, formed by a formal 1,2-prototropic shift, in low to moderate yield in xylene or ethanol.
61 citations
TL;DR: The 1,4-dianions of C(α),N-carboalkoxyhydrazones and N-phenyl hydrazones were prepared in an excess of lithium diisopropylamide (LDA) as mentioned in this paper.
50 citations
TL;DR: N-Aroylhydrazones of o-hydroxyaryl ketones are oxidized with lead(IV)acetate to aromatic o-diketones in a synthetically useful reaction.
38 citations
Patent•
09 Feb 1987
TL;DR: In this paper, an immunoglobulin (IgG) through a carbohydrate on the Fc or hinge regions has been found to provide very high binding capacity approaching the theoretical bivalent limit of two moles of bound antigen for every mole of bound immunoglobalulin.
Abstract: A biological composition comprises a solid phase support matrix or marker molecule bound to protein, typically a glycoprotein such as an immunoglobulin through a linking group, spacer arm, and hydrazone group. The linking group is conveniently an ether linkage, while the spacer arm is a linear chain including six atoms, where at least one of the atoms is a tertiary amine which is protonated at a pH below about 8. The hydrazone is formed by reacting the solid phase or marker molecule having the linking arm and the spacer arm including a terminal hydrazide group with a glycoprotein oxidized to include a terminal aldehyde group. Immunological reagents prepared by linking an immunoglobulin (IgG) through a carbohydrate on the Fc or hinge regions have been found to provide very high binding capacity approaching the theoretical bivalent limit of two moles of bound antigen for every mole of bound immunoglobulin.
33 citations
TL;DR: Synthese d'alkylazo-1-and phenylazone-1 chloro-2' benzyl-2 methyl-1 perhydro indolizidinones-2 a partir d'acetyl-pyridine via des derives d"acetohydrazonoyl-2" piperidides d'acide chloroxide-2 cinnamique as discussed by the authors.
Abstract: Synthese d'alkylazo-1- et phenylazo-1 chloro-2' benzyl-2 methyl-1 perhydro indolizidinones-2 a partir d'acetyl-2 pyridine via des derives d'acetohydrazonoyl-2' piperidides d'acide chloro-2 cinnamique
33 citations
TL;DR: A simple, rapid and sensitive spectrophotometric method is described for determining carbaryl, propoxur, fenitrothion and methyl parathion based on reaction of their hydrolysis or reduction products with 3-methyl-2-benzothiazolinone hydrazone hydrochloride in the presence of an oxidant or Fe(3+) to give coloured species.
31 citations
TL;DR: In this paper, a new metal complex of 2,6-diacetylpyridine bis(salicyloylhydrazone)(H2daps) has been prepared from the reaction of the hydrazone with Co, Ni, Cu, Zn, and Cd chlorides and acetates.
Abstract: Some new metal complexes of 2,6-diacetylpyridine bis(salicyloylhydrazone)(H2daps) have been prepared from the reaction of the hydrazone with Co, Ni, Cu, Zn, and Cd chlorides and acetates. The chelating behaviour of the hydrazone has been spectroscopically investigated in all compounds by means of i.r. and 1H n.m.r. techniques. The complex [Cd(H2daps)Cl2]·CHCl3·CH3OH has been subject to an X-ray analysis which established a seven-co-ordinate pentagonal-bipyramidal metal environment, with two axial Cl atoms and the H2daps ligand forming the basal plane.
29 citations
Patent•
07 Oct 1987TL;DR: In this paper, an antineoplastic indole-dihydroindole vinca alkaloid containing a hydrazine group attached at C-3 or C-4 with an oxidized glycoprotein containing aldehyde groups was formed.
Abstract: Immunoglobulin conjugates formed by reaction of an antineoplastic indole-dihydroindole vinca alkaloid containing a hydrazine group attached at C-3 or C-4 with an oxidized glycoprotein containing aldehyde groups.
28 citations
Patent•
05 Jan 1987
TL;DR: In this article, a method and apparatus for detecting hydrazine, monomethylhydrazine (MMH), and unsymmetrical dimethylhydrazines (UDMH) in a gaseous sample is described.
Abstract: Disclosed is a method and apparatus for detecting hydrazine, monomethylhydrazine (MMH), and unsymmetrical dimethylhydrazine (UDMH) in a gaseous sample. The hydrazine compound detector includes a sample converter wherein vapors of an aldehyde such as acetaldehyde or a ketone such as acetone are mixed with a sample in gaseous form, and the mixture is allowed to react to form azine and hydrazone derivatives of the aldehyde or ketone. The derivatives may be transported long distances and then analyzed, as by heating in the presence of an oxidant in a pyrolyzer containing a nickel surface to produce nitric oxide (NO), followed by measurement of the NO in a NO detector such as a chemiluminescent analyzer.
TL;DR: In this paper, the UO 2 2+ group is maintained in all these complexes with the ligand atoms arranged in the equatorial plane perpendicular to the linear uranyl group, indicating that the ligands function as tetrabasic hexadentate ligands.
TL;DR: In this paper, a dioxouranium (VI) complex with the dibasic tridentate 7-carboxaldehyde-8-hydroxyquinoline-aroylhydrazone derivatives was synthesized and is bonded to the axial oxygen of the uranyl moiety and is easily substituted by dimethylsulphoxide.
Abstract: New dioxouranium(VI) complexes with the dibasic tridentate 7-carboxaldehyde-8-hydroxyquinoline-aroylhydrazone derivatives (1), have synthesized and is bonded to the axial oxygen of the uranyl moiety and is easily substituted by dimethylsulphoxide. The ligands contain intramolecular hydrogen bonds, one of which is from the enolic form of the hydrazone residue. The1H n.m.r. spectra show that the position of the hydrogenbonded proton of the hydrazone moiety is substituent dependent. The F(U−O) (mydn/A) and the bond length r(U−O) (A) of the UO bond are calculated from the i.r. data and related to the electronic properties of the substituents.
TL;DR: In this article, the Fischer indolization of 6-arylhydrazono-1,2,3,4,6,7,8,9-octahydro-11H-pyrido-[2,1-b]quinazolin-11-ones is described.
TL;DR: In this paper, the title compounds using the hydrazone 3 as starting material are reported, and synthesen der Titelverbindungen aus dem Hydrazon 3 werden beschrieben.
Abstract: Syntheses of the title compounds using the hydrazone 3 as starting material are reported.
Untersuchungen mit Heterocyclischen Hydrazidhalogeniden: Neue Pyrazolo[5,1-c]-1,2,4-triazole und Pyrazolo[5,1-c][1,2,4]triazine
Synthesen der Titelverbindungen aus dem Hydrazon 3 werden beschrieben.
TL;DR: One-pot synthesis of symmetrical pyrroles was obtained by reaction of alkylhydrazones of enolizable ketones, PCl3, and subsequent addition of the same ketone.
Abstract: A one-pot synthesis of symmetrical pyrroles was obtained by reaction of alkylhydrazones of enolizable ketones, PCl3, and subsequent addition of the same ketone.
IBM1
TL;DR: In this paper, a photocyclization followed by an oxidation of thin films of p-diethylaminobenzaldehyde diphenyl-hydrazone is proposed.
TL;DR: The reaction of the quinoxaline 1 with 4-ethoxycarbonyl-1H-pyrazole-5-diazonium chloride 7 at room temperature gave 3]-α-(4-ethoxcarbonyls-1-H pyrazol 5-ylhydrazono)methoxy carbonylmethyl]-2-oxo-1,2-dihydropyrazolo[5,1-c]triazine 9 Compound 9 was also obtained directly by the reaction of 1 with 7 under reflux in better yield
TL;DR: In this article, N,N-Dialkylhydrazones are efficiently cleaved back to their parent ketones under mild conditions at pH 7, and the oxidative hydrolysis is effected in good yields with the very cheap bulk chemical sodium perborate in buffer solution and tertbutanol as cosolvent.
Abstract: Abstract N,N-Dialkylhydrazones, such as dimethyl- and SAMP-hydrazones, are efficiently cleaved back to their parent ketones under mild conditions at pH 7. The oxidative hydrolysis is effected in good yields with the very cheap bulk chemical sodium perborate in buffer solution and tert-butanol as cosolvent.
TL;DR: The 13 C and 15 N-NMR spectra of phenylazoacetoacetamides have been measured and the carbon and nitrogen signals have been assigned and the compounds exist in their hydrazone forms based on the stereospecific behaviour of the coupling constants as discussed by the authors.
TL;DR: In this paper, the X-ray crystallographic data for the title hydrazone, C10H7N5O5, is described, and the structure has been determined by direct methods and refined to R 0.074.
Abstract: Eight phenylhydrazone derivatives of pyrimidine-2(1H),4(3H),5,6-tetraone, or 5-oxobarbituric acid (alloxan), are described. Spectroscopic pyrimidine (1H n.m.r., i.r.) data indicate the presence of extensive hydrogen bonding which, as shown by X-ray crystallographic data for the title hydrazone, includes both intra- and inter-molecular interactions. The title hydrazone, C10H7N5O5, is monoclinic, space group P21/a, a= 9.104(8), b= 17.975(13), c= 10.333(8)A, β= 113.5(1)°, Z= 4.2145 Independent reflections have been measureed on a diffractometer and the structure has been determined by direct methods and refined to R 0.074. There are four independent hydrogen bonds in the asymmetric unit: two intramolecular bonds which link N(7)–H(7) to an o-NO2 group of the benzene ring and to a carbonyl group of the barbiturate ring and two intermolecular bonds which link NH sites of the barbiturate ring to a solvent NN-dimethylformamide oxygen atom and to a carbonyl oxygen atom of another barbiturate ring across a centre of symmetry.
TL;DR: In this paper, various tosylhydrazones, such as dialkyl and aryl-alkyl-tosyl-to-sylhexones, were found to react with peroxysulfur intermediate, which was generated by the reaction of 2-nitrobenzenesulfonyl chloride with superoxide, to be converted into the corresponding carbonyl compounds, in mostly quantitative yields, at −30°C under mild conditions.
Patent•
06 May 1987
TL;DR: In this paper, a specific hydrazone compd and dye having the absorption max. at 450-500nm are incorporated into the charge transfer layer of a separated function type photosensitive body.
Abstract: PURPOSE:To prevent deterioration in the characteristic of a separated function type photosensitive body provided with an electric charge generating layer and charge transfer layer on a conductive substrate by incorporating a specific hydrazone compd. and dye having the absorption max. in a prescribed range into the charge transfer layer of said body. CONSTITUTION:The hydrazone compd. expressed by the formula is not affected by the light harmful thereto and the deterioration in the characteristics of the photosensitive body based on photoirradiation is suppressed if the above- mentioned hydrazone compd. and the dye having the absorption max. at 450-500nm are incorporated into the charge transfer layer. In the formula, X, Y: respectively independent hydrogen, lower alkyl group, methoxy group or ethoxy group; Z lower alkyl group, benzyl group, lower alkoxy group, phenoxy group or benzyloxy group, Z': hydrogen, alkyl group or alkoxy group, R: lower alkyl group, aryl group or benzyl group which may have a substitutent.
TL;DR: In this article, the reaction of N-phenyl-3-carboalkoxy-5-alkoxy substituted pyrazoles with carboalkoxymethylene triphenylphosphoranes has been examined.
TL;DR: In this paper, unsymmetrically disubstituted hydrazines were condensed with carbonyl compounds and some of the expected condensation products were isolated, but some were formed as unstable intermediates which underwent 1,4-elimination.