Showing papers on "Hydrazone published in 2009"
TL;DR: Two novel 2-oxo-quinoline-3-carbaldehyde (4'-hydroxybenzoyl) hydrazone, thiosemicarbazone ligands and its corresponding Cu(2+) complexes were synthesized, and the two complexes' structures were determined by X-ray single crystal diffraction.
252 citations
TL;DR: A macrocyclic hydrazone Schiff base was synthesized by reacting 1,4-dicarbonyl phenyl dihydrazide with 2,6-diformyl-4-methyl phenol and a series of metal complexes with this new Schiff base were synthesised by reaction with Co(II), Ni(II) and Cu(II).
220 citations
TL;DR: A series of novel 3-aryl-1-(4- tert -butylbenzyl) -1 H -pyrazole-5-carbohydrazide hydrazone derivatives were synthesized and the effects of all the compounds on A549 cell growth were investigated as mentioned in this paper.
133 citations
TL;DR: Bis-acyl-/aroyl-hydrazones can be divided into two basic structural categories: those derived from a dihydrazide and those that are derived from dialdehyde (or diketone).
132 citations
TL;DR: A novel series of 1, 4-bis(6-(substituted phenyl)-[1,2,4]-triazolo[3,4-b]-1,3,5-thiadiazole-2yl derivatives have been synthesized from terephthalic dihydrazide through multistep reaction sequence and showed potential antibacterial activity.
119 citations
TL;DR: New 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(p-subStituted benzal)hydrazone V derivatives were synthesized as analgesic and anti-inflammatory agents and exhibited more potent analgesic activity than ASA.
116 citations
TL;DR: In this paper, the crystal structures of 2-Benzoylpyridine-methyl hydrazone (HBzMe) have been determined and its copper(II) [Cu(Bzme)Cl2] (1) and zinc(II] [Zn(HBzME)Cl 2] (2) complexes have been obtained.
114 citations
TL;DR: The antioxidant activity experiments show that these compounds also exhibit good antioxidant activities against (*)OH and O(2)(-).
105 citations
TL;DR: In this paper, the tridentate hydrazone pro-ligand (HPBH) is obtained by the condensation of benzhydrazide and pyridine-2-carboxaldehyde.
88 citations
TL;DR: The synthesis and evaluation of new analogues of thieno[2,3-d]pyrimidin-4-yl hydrazones are described and the potency, selectivity profile, and structure-activity relationship of this series of compounds are discussed.
88 citations
TL;DR: In this article, the catalytic properties of 9−15 in the Suzuki−Miyaura cross-coupling of the aryl bromides 4-R2C6H4Br (R2 = H, Me, OMe, and NO2) with phenylboronic acid (in EtOH as a solvent, K2CO3 as a base, 80 °C), yielding biaryl...
TL;DR: A thin and well-defined film of covalently attached benzaldehyde with an estimated coverage of 4 x 10(-10) mol cm(-2) was formed and the electrochemical responses of benzaldehyde were highly reproducible and largely independent of grafting medium and along with that also the thickness of the initially grafted film.
Abstract: A methodology is described for introducing a thin layer of covalently attached benzaldehyde on glassy carbon surfaces using aryl diazonium chemistry. Usually the electroreduction of aryl diazonium salts leads to the formation of an ill-defined multilayer because of the involvement of highly reactive aryl radicals that can add to already-grafted aryl groups. However, in this study we used a two-step “formation-degradation” procedure to solve this problem with the first step consisting of an electrografting of an aryl diazonium salt of a long-chain and bulky alkyl hydrazone onto a glassy carbon surface. The design of the hydrazone group serves to minimize multilayer formation by greatly diminishing the grafting rate after the first-layer formation and at the same time preventing radical additions from taking place at the inner aryl ring. Another valuable property of the hydrazone group is that it easily can be deprotected to the corresponding aldehyde by acid hydrolysis (i.e., the degradation step). In this...
TL;DR: The antiviral activity of the new compounds against Hepatitis A Virus using the plague infectivity reduction assay revealed that the acridine 4 and the hydrazone 12 were more active than the reference drug amantadine.
TL;DR: It is demonstrated that DNPH is not exclusively selective for carbonyl groups, because it also reacts with sulfenic acids, forming a DNPH adduct, through the acid-catalyzed formation of a thioaldehyde intermediate that is further converted to an aldehyde.
TL;DR: In this article, the crystal structures of 2-formylpyridine-para-chloro-phenyl hydrazone (H2FopClPh) and H2FOPNO2Ph were obtained, as well as their copper and zinc complexes.
TL;DR: Known protocols for hydrazone oxidation were adapted to permit facile access to a range of mono- and disubstituted aryl- or alkyldiazomethanes in pure form in solution, and the discovery that commercial Sc(III) salts are efficient catalysts for net insertion of the diazoalkyl carbon in these nucleophiles into the carbonyl C-C bond of simple cycloalkanones is discovered.
Abstract: Though volatile, toxic, and unstable, diazomethane is an indispensable one-carbon reagent with manifold uses in chemical synthesis. In this work, known protocols for hydrazone oxidation were adapted to permit facile access to a range of mono- and disubstituted aryl- or alkyldiazomethanes in pure form in solution; such procedures proceed in 30−60% overall yield starting from inexpensive carbonyl compounds. More important is the discovery that commercial Sc(III) salts are efficient catalysts for net insertion of the diazoalkyl carbon in these nucleophiles into the carbonyl C−C bond of simple cycloalkanones. In a single step, these reactions (1) forge two new C−C bonds under mild conditions, (2) produce molecular nitrogen as the sole stoichiometric byproduct, and (3) afford high yields of complex α-tertiary and -quaternary cyclic ketones that are typically accessible only through multistep procedures.
TL;DR: In this paper, the synthesis of the hydrazone ligands, 1-(phenyl-hydrazono)-propan-2-one (PHP), 1-( p -tolyl-hydrasono)propan 2-one, 1-[(4-chloro]-hydrazone]--propan 3-1 (CHP), and their corresponding metal complexes were investigated using elemental analysis, magnetic susceptibility, molar conductance and spectral (IR, UV, and EPR) measurements.
TL;DR: Electronic absorption spectroscopy, fluorescence spectra, ethidium bromide displacement experiments, iodide quenching experiments, salt effect and viscosity measurements indicate that the ligand and Ln(III) complexes, especially the Nd( III) complex, strongly bind to calf thymus DNA, presumably via an intercalation mechanism.
TL;DR: The newly synthesized compounds have been characterized by FTIR, (1)H NMR, (13)C NMR and mass spectral data, followed by elemental analysis, and exhibited promising results.
TL;DR: Both of 3-(3-methylbenzofuran-2-yl)-3-oxopropanenitrile and 3-methyl- 2-benz ofuranoyl chloride were used as starting materials for the synthesis of several compounds, such as pyrazoles 10 and 14, oxime 11, hydrazones 12a, b and 3,1-bezoxazine 19.
TL;DR: The hydrazone derivative 15(d) (1-[4-methoxybenzyl)-6-methylphenyl pyridazin-3(2H)-ylidene]-2-(2-carboxydiphenyl methyl) hydrazine) showed the highest biological activity.
TL;DR: In this paper, the synthesis, FT-IR, 1H and 13C NMR characterisation, as well as crystal and molecular structure determined by single-crystal X-ray diffraction data, of two azo dyes derived from 6-aminobenzothiazole: 6-[(4-N,N-dimethylaminophenyl)diazenyl]benzothiazoles and 6-[ (2-hydroxy-1-naphthyl)-diamethyl]-benzostiazole are reported.
TL;DR: The design, synthesis and evaluation of novel thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as cyclin-dependent kinase 4 (CDK4) inhibitor are described.
TL;DR: In this article, the X-ray crystal structure of pseudotetrahedral [Zn(HL 1 )2]� 1.75MeOH confirmed the O,N coordination mode of the two monodeprotonated ligands in their keto forms.
TL;DR: In this article, the effects of varying solvents, bases, and ligand/palladium ratios on the performance of the Suzuki-Miyaura coupling reaction were investigated.
TL;DR: Preliminary biological evaluation showed that one compound inhibits the growth of A549 cells at 20microM, and the structures of the compounds were determined by IR, (1)H NMR, and HRESIMS.
TL;DR: The results may be instructive to researchers attempting to gain more understanding of the antimicrobial activity of indole hydrazide/hydrazone-type compounds.
Abstract: Background: Indoles and hydrazone-type compounds constitute an important class of compounds for new drug development in order to discover an effective compound against multi-drug-re
TL;DR: In this article, an hydrazone Schiff base-iron (III) complex using salicylidene benzoyl hydrazine (L) as ligand has been synthesized and characterized by elemental analyses, IR, 1H and 13C NMR and UV-Vis spectroscopy.
TL;DR: Visual color changes accompany guest binding, enabling this system to act as colorimetric anion sensors, and results indicate that the receptor without NO2 shows no binding ability for various anions.
Abstract: A series of artificial receptors, hydrazone derivatives containing anthracene, have been designed and synthesized. The interaction of these receptors with biologically important anions was determined by UV-vis, fluorescence and 1H NMR titration experiments and theoretical investigation. Results indicate that the receptor (1) without NO2 shows no binding ability for various anions. The other receptors (2 and 3) show the highest binding ability for acetate (AcO-) among studied anions (fluoride (F-), dihydrogen phosphate (H2PO4-), chloride (Cl-), bromide (Br-), iodide (I-)); and the binding ability for AcO- is not interfered by the existence of other anions. The additions of AcO-, F- and H2PO4- can arouse different degrees of fluorescence quenching. 1H NMR titration shows that the interaction between the receptor 2 and F- firstly depends on the hydrogen-bond formation; later the interacted site NH is deprotonated and the added F- forms hydrogen bond with the near CH in Schiff base. Moreover, visual color changes accompany guest binding, enabling this system to act as colorimetric anion sensors.
TL;DR: Aryllithium reagents were used in Fischer indole synthesis as mentioned in this paper, where the aryl hydrazones were converted into indoles in good yields by heating with thionyl chloride in alcohol.