Hydrazone

About: Hydrazone is a research topic. Over the lifetime, 4853 publications have been published within this topic receiving 65160 citations. The topic is also known as: hydrazone.

Synthesis and antimicrobial activity of some new hydrazone-bridged thiazole-pyrrole derivatives.

Abstract: In this work, we synthesized fourteen different compounds which contain hydrazone bridged thiazole and pyrrole rings. For this purpose, pyrrole-2-carboxaldehydes were reacted directly with thiosemicarbazide in ethanol and then obtained thiosemicarbazones were condensed with α-bromoacetophenone derivatives (Hantzsch reaction) to give 1-substituted pyrrole-2-carboxaldehyde [4-(4-substituted phenyl)-1,3-thiazol-2-yl] hydrazones. The structures of the obtained compounds were elucidated by using IR, (1)H-NMR and FAB(+)-MS spectral data and elemental analyses results. All of the compounds were screened for their antibacterial and antifungal activities against twelve different microorganisms by using microbroth dilution method. Ketoconazole and chloramphenicol were used as standard drugs. All of the compounds showed good activity against Staphylococcus aureus and Enterococcus faecalis.

Determination of aldehydic lipid peroxidation products with dabsylhydrazine by high-performance liquid chromatography

Abstract: A high-performance liquid chromatographic method has been developed to measure adlehyde products of lipid peroxidation including n-alkanals, trans-2-alkenals, 4-hydroxy-2-nonenal, and malonaldehyde. The chromophoric reagent dabsylhydraue reacts with various aldehydes produced from two different lipid peroxidation model systems: Fe 2+ /H 2 O 2 and Fe 2+ /vitamin C oxidation of arachidonic and linoleic acids, respectively. The formed products were carefully characterized by IR, MS, and NMR spectral analysis and proved to be hydrazone rather than 2-pyrazoline or pyrrole derivatives. EI-MS of all the derivatized straight-chain aldehydes showed a characteristic (M-28) fragment in the spectra with high, consistency. Physicochemical properties including melting points are also described. The detection limits in the range of 11 pmol (5 ng) have been reached by using an NP Octadecyl C 18 reversed-phase column. 4-Hydroxy-2-nonenal and hexanal were found to be the most abundant aldehydes in the lipid peroxidation systems described. The dose-response curve showed great linearity and exhibited good reproducibility of this procedure for quantitative estimation

Synthesis of Anthranilic Diamide Derivatives Containing Moieties of Trifluoromethylpyridine and Hydrazone as Potential Anti-Viral Agents for Plants.

Abstract: A series of novel anthranilic diamide derivatives (5a–5ab) containing moieties of trifluoromethylpyridine and hydrazone was designed and synthesized. The synthesized compounds were evaluated in viv...

Synthesis, characterization, electrochemical behavior, and antimicrobial activities of aromatic/heteroaromatic sulfonylhydrazone derivatives

Abstract: The aromatic/heteroaromatic sulfonylhydrazone derivatives as indole-3-carboxaldehyde methanesulfonylhydrazone (1), indole-3-carboxaldehydeethanesulfonyl hydrazone (2), thiophene-2-carboxaldehydeethanesulfonylhydrazone (3), 2-hydroxybenzaldehydeethanesulfonyl hydrazone (4), 2-hydroxyacetophenoneethanesulfonylhydrazone (5) and 2-hydroxy-1-naphth aldehydeethane sulfonylhydrazone (6) were synthesized by the reaction of sulfonic acids with aromatic/heteroaromatic aldehydes and characterized by using elemental analysis, 1H–13C NMR, LC–MS and IR spectra. The electrochemical behavior of the sulfonylhydrazones in DMSO at glassy carbon electrode was investigated using cyclic voltammetry, controlled potential electrolysis and chronoamperometry techniques. The number of electrons transferred, diffusion coefficient and standard heterogeneous rate constants were determined using electrochemical methods. Antimicrobial activities of the compounds 1–6 were tested against some microorganisms. The biological activity screening showed that compound 6 exhibited better activity than the others. Structure–activity relationship analysis of the sulfonylhydrazone derivatives was performed to explain the trend of activity with molecular descriptors. The indicator descriptors for compound 6 having naphtyl ring are the most important descriptos that are sensitive both to the size and electrophility of the molecules.