Topic
Hydrazone
About: Hydrazone is a research topic. Over the lifetime, 4853 publications have been published within this topic receiving 65160 citations. The topic is also known as: hydrazone.
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TL;DR: A series of pyrazole derivatives 4, 5, 6, 12, 13, 14 as well as hydrazone derivatives 7, 10, 11 were synthesized starting from adamantane-1-carbohydrazide as the bioactive core.
33 citations
TL;DR: In this paper, the effects of the π-p conjugation at the carboxylic acid amide group have been discussed, and the effects upon the spectra of the intramolecular hydrogen bond and of π p conjugations at the amide groups have been investigated.
Abstract: Phenylazoacetoacetanilide and its related compounds have the hydrazone structure. The phenylazoacetoacetic acid ethylester, for example, forms an intramolecular hydrogen bond between a ketone group and a hydrazone group in the solid state and in non-polar solvents. The electronic absorption spectra exhibit three groups of bands—A,B and C—D. The effects upon the spectra of the intramolecular hydrogen bond and of the π-p conjugation at the carboxylic acid amide group have been discussed.
33 citations
TL;DR: In this paper, ortho-substituted [Cr(CO)3(benzaldehyde)] complexes are obtained via nucleophilic addition of alkyl-and aryllithium reagents to a [Cr[CO]3(phenylmethaneimine)] complex followed by endo-hydride abstraction with triphenylmethyl cation.
Abstract: ortho-Substituted [Cr(CO)3(benzaldehyde)] complexes are obtained via nucleophilic addition of alkyl- and aryllithium reagents to a [Cr(CO)3(phenylmethaneimine)] complex followed by endo-hydride abstraction with triphenylmethyl cation. This sequence, when carried out with a [Cr(CO)3(benzaldehyde SAMP hydrazone)] complex affords substituted derivatives (Me, Bu, Ph, vinyl) with high (=/>97%) diastereoselectivity and, after hydrolysis, ortho- substituted [Cr(CO)3(benzaldehyde)] ((S)-1) complexes of high enantiomeric purity.
33 citations
TL;DR: In this paper, a novel fluorescent Al 3+ -sensor (8-Hydroxyquinoline-7-aldehyde-(2′-methylquinoline)-4′-formyl hydrazone, L 1 ) based on quinoline derivative has been designed and synthesized.
33 citations
Patent•
09 Feb 1987
TL;DR: In this paper, an immunoglobulin (IgG) through a carbohydrate on the Fc or hinge regions has been found to provide very high binding capacity approaching the theoretical bivalent limit of two moles of bound antigen for every mole of bound immunoglobalulin.
Abstract: A biological composition comprises a solid phase support matrix or marker molecule bound to protein, typically a glycoprotein such as an immunoglobulin through a linking group, spacer arm, and hydrazone group. The linking group is conveniently an ether linkage, while the spacer arm is a linear chain including six atoms, where at least one of the atoms is a tertiary amine which is protonated at a pH below about 8. The hydrazone is formed by reacting the solid phase or marker molecule having the linking arm and the spacer arm including a terminal hydrazide group with a glycoprotein oxidized to include a terminal aldehyde group. Immunological reagents prepared by linking an immunoglobulin (IgG) through a carbohydrate on the Fc or hinge regions have been found to provide very high binding capacity approaching the theoretical bivalent limit of two moles of bound antigen for every mole of bound immunoglobulin.
33 citations