Topic
Hydrazone
About: Hydrazone is a research topic. Over the lifetime, 4853 publications have been published within this topic receiving 65160 citations. The topic is also known as: hydrazone.
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Patent•
18 Feb 1982
TL;DR: In this paper, the authors described electrophotographic light sensitive elements containing substituted or unsubstituted fluorenone hydrazones as charge generating or charge transport materials, respectively.
Abstract: Electrophotographic light-sensitive elements containing substituted or unsubstituted fluorenone hydrazones as charge generating or charge transport materials are described.
30 citations
TL;DR: In this article, the 4-disubstituted β-lactams (4a-c and 6a-b) were prepared through the reaction of N,N-diphenylhydrazones and N-methyl-N-phenyl hydrazones of ketones with phenoxyacetyl chloride/Et 3 N in dichloromethane.
Abstract: Phenoxyketene is capable of annelating the disubstituted hydrazones to afford stereoselectively cis-monocyclic β-lactams with a 1-amino functionality. The ease of cycloaddition is governed by substituents on the azomethine carbon as well as on the hydrazone nitrogen. The 4-disubstituted β-lactams (4a-c and 6a-b) were prepared through the reaction of N,N-diphenylhydrazones and N-methyl-N-phenylhydrazones of ketones with phenoxyacetyl chloride/Et 3 N in dichloromethane. A similar reaction using aldehyde and ketone hydrazones, derived from N,N-dimethylhydrazine, produced 4-monosubstituted (8a-d) as well as 4-disubstituted (8e-1) β-lactams in good yields
30 citations
TL;DR: A series of novel diarylpyrimidines with a ketone hydrazone substituent on the methylene linker between the pyrimidine nucleus and the aryl moiety at the C‐4 position were synthesized, and their antiviral activity against human immunodeficiency virus (HIV)‐1 in MT‐4 cells was evaluated.
Abstract: A series of novel diarylpyrimidines (DAPYs) with a ketone hydrazone substituent on the methylene linker between the pyrimidine nucleus and the aryl moiety at the C-4 position were synthesized, and their antiviral activity against human immunodeficiency virus (HIV)-1 in MT-4 cells was evaluated. Most compounds of this class exhibited excellent activity against wild-type HIV-1, with EC(50) values in the range of 1.7-13.2 nM. Of these compounds, 2-bromophenyl-2-[(4-cyanophenyl)amino]-4-pyrimidinone hydrazone (9k) displayed the most potent anti-HIV-1 activity (EC(50) =1.7±0.6 nM), with excellent selectivity for infected over uninfected cells (SI=5762). In addition, the 4-methyl phenyl analogue 9d (EC(50) =2.4±0.2 nM, SI=18461) showed broad spectrum HIV inhibitory activity, with EC(50) values of 2.4±0.2 nM against wild-type HIV-1, 5.3±0.4 μM against HIV-1 double-mutated strain RES056 (K103N+Y181C), and 5.5 μM against HIV-2 ROD strain. Furthermore, structure-activity relationship (SAR) data and molecular modeling results for these compounds are also discussed.
30 citations
TL;DR: The relationship between the substituted group types and the UV fluorescence spectral properties, as well as the fluorescence quantum yields of the title Schiff bases were investigated in this article, and the results showed that the introduction of both the donating and accepting electron groups causes various grade redshifts of fluorescence characteristic emission peak of the Schiff bases to occur.
30 citations
TL;DR: In this paper, the synthesis and chemical properties of some 2 and 3-substituted furo[2,3-b]pyridines were described, and a 2-methyl derivative was obtained by reduction, O-acetylation and subsequent pyrolysis.
30 citations