Topic
Hydrazone
About: Hydrazone is a research topic. Over the lifetime, 4853 publications have been published within this topic receiving 65160 citations. The topic is also known as: hydrazone.
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TL;DR: The aim was to evaluate the importance of a bulky group at C2, C4, and C5 positions of the thiazole nucleus in modulating the biological activity of this scaffold.
Abstract: A large class of (4,5-substituted-thiazol-2-yl)hydrazone derivatives (1–66) was synthesized in good yield (82–99%) and characterized by elemental analysis and 1H NMR studies. The compounds were assayed for their in vitro human monoamine oxidase inhibitory activity and selectivity. Most of them showed IC50 values in the micromolar range. Our aim was to evaluate the importance of a bulky group at C2, C4, and C5 positions of the thiazole nucleus in modulating the biological activity of this scaffold.
28 citations
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TL;DR: The cyclization of hydrazone dianions with diethyl oxalate afforded pyrazole-5-carboxylates as discussed by the authors, and the cyclization was shown to yield pyrazolines.
28 citations
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TL;DR: The hydrazide-hydrazone derivative 1 was formed through the reaction of cyanoacetic acid hydrazides with 2-acetylfuran as discussed by the authors, and it underwent a series of hetrocyclization reactions through its reaction with different chemical reagents to produce arylidene, coumarin, ayrl hydrazone, pyridine, thiophene and thiazole derivatives.
Abstract: The hydrazide-hydrazone derivative 1 was formed through the reaction of cyanoacetic acid hydrazide with 2-acetylfuran. Compound 1 underwent a series of hetrocyclization reactions through its reaction with different chemical reagents to produce arylidene, coumarin, aryl hydrazone, pyridine, thiophene and thiazole derivatives 2–10. The MIC values for the newly synthesized products were tested against E. coli, B. cereus, B. subtilis and C. albicans compared with ampicilline and cycloheximide as reference drugs.
28 citations
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TL;DR: Intermediates 4 and 5 have been coupled via a Shapiro reaction to afford compound 6 which has been further elaborated to the ABCtaxcid systems 11and 12via a McMurry pinacol cyclization to 11followed by oxidation to 12.
Abstract: Intermediates 4 and 5have been coupled via a Shapiro reaction to afford compound 6 which has been further elaborated to the ABCtaxcid systems 11and 12via a McMurry pinacol cyclization to 11followed by oxidation to12.
28 citations
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TL;DR: A series of new hydrazone mononuclear complexes of the type [(arene)MLCl]PF6 (M = Ru, Rh, Ir) have been synthesized in this article.
28 citations