Topic
Hydrazone
About: Hydrazone is a research topic. Over the lifetime, 4853 publications have been published within this topic receiving 65160 citations. The topic is also known as: hydrazone.
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TL;DR: The use of 2,4-dinitrophenyl hydrazine as a reagent for the estimation of methyl ketones and other carbonyls is common despite the fact that the reaction is apparently non-quantitative.
Abstract: THE use of 2,4-dinitrophenyl hydrazine (2,4-DNP hydrazine) in acid solution as a reagent for the estimation of methyl ketones and other carbonyls is common despite the fact that the reaction is apparently non-quantitative1–3. Between 20 and 90 per cent recoveries of methyl ketones from aqueous solution have been reported4,5. Wong, Patton and Forss4 attributed the low recovery of 2-pentanone (25 per cent) from whole milk by steam distillation under reduced pressure to the non-completion of the reaction with the reagent. Haverkamp Begemann and de Jong5 concluded that the method of shaking had a marked influence on the yield of 2,4-DNP hydrazone, and by use of ‘Celite’ /2,4-DNP hydrazine column to ensure more intimate contact between the reagent and the carbonyl compound they achieved practically complete conversion into the 2,4-DNP hydrazone.
28 citations
TL;DR: Unprecedented noradamantane-type compounds, containing a Ge-Ge bond, yield from reactions of R(2,3)GeCl(3) with Na(2)Te or Li( 2)Te in THF, and by reaction with hydrazine, the latter reacts to the hydrazone functionalized, monomeric anion.
28 citations
TL;DR: In this article, the azo-hydrazone tautomerism of three azopyrrole compounds, which were synthesized by the reactions of 2-acylbenzenediazonium salt with pyrrole and meso-diethyl-2,2′-dipyrromethane, have been studied.
28 citations
TL;DR: All the derivatives showed good CNS depressant activity and showed protection in the MES test, indicative of their ability to inhibit the seizure spread, and were nontoxic.
Abstract: A series of 2-(substituted-phenyl)-3-(2-oxoindolin-3-ylidene)amino)-thiazolidin-4-one derivatives were designed and synthesized under microwave irradiation, using an eco-friendly, efficient, microwave-assisted synthetic protocol that involves cyclocondensation of 3-substituted benzylidine-hydrazono-indolin-2-one 3a-j with thioglycolic acid in dimethyl formamide (DMF) as solvent and anhydrous zinc chloride as a catalyst, keeping in view the structural requirement of the pharmacophore. The intermediate compounds 3a-j were obtained by condensation of the hydrazone of indoline-2,3-dione with aromatic aldehydes. The synthesized derivatives were evaluated for CNS depressant activity and anticonvulsant activity in mice using the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (sc-PTZ) induced seizure tests. All the derivatives showed good CNS depressant activity and showed protection in the MES test, indicative of their ability to inhibit the seizure spread. A histopathological study was performed to evaluate liver toxicity caused by the synthesized compounds. The compounds were nontoxic. A computational study was performed, in which log P values were calculated experimentally. Virtual screening was performed by molecular docking of the designed compounds into the ATP binding sites of the NMDA and AMPA receptors, to predict if these compounds have analogous binding modes.
28 citations
TL;DR: A new dinuclear complex of Co(III), [Co(L 1′ )(μ-N 3 )(N 3 )] 2 ( 1 ) and a mononuclear complex as discussed by the authors were synthesized and characterized by elemental analyses, spectroscopic methods and X-ray diffraction analyses [L 2 is (E )-2-(1-(2-(perfluorophenyl)hydrazono)ethyl)pyridine]
28 citations