Topic
Hydrazone
About: Hydrazone is a research topic. Over the lifetime, 4853 publications have been published within this topic receiving 65160 citations. The topic is also known as: hydrazone.
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TL;DR: In this paper, a complete and detailed study of the hydrazone obtained from condensation of antituberculous isoniazid (hydrazide of the isonicotinic acid, INH) and o -vanillin (2-hydroxy-3-methoxybenzaldehyde, o -HVa) is performed.
28 citations
TL;DR: The first asymmetric synthesis of conium conium alkaloid (−)-α-conhydrine is reported in this paper, starting from a protected glycol aldehyde hydrazone as chiral precusor, a short route based on α-alkylation/1,2addition methodology has been developed.
Abstract: The first asymmetric synthesis of the conium alkaloid (−)-α-conhydrine is reported. Starting from a protected glycol aldehyde hydrazone as chiral precusor, a short route based on our α-alkylation/1,2-addition methodology has been developed. After cleavage of the auxiliary and simultaneous deprotection, the concluding ring closure is accomplished under reductive amination conditions. The title compound is obtained in moderate overall yield and in excellent diastereo- and enantiomeric excess (d.e., e.e. >96%). Single-crystal X-ray crystallography as well as 1H NMR NOE experiments confirm the expected relative and absolute (2R,7S)-configuration of the product.
28 citations
TL;DR: In this paper, the spatial structure of pyridoxal 5′-phosphate hydrazones of 2-furoic hydrazide; thiophene-2-carboxylic hydrazides in aqueous solution was studied by means of quantum chemical calculations and NOE experiment.
28 citations
TL;DR: In this article, NMR spectroscopic and chemical investigations prove that compounds hitherto considered to be 1,3,4-thiadiazolidine-2-thiones are, in solution, in a tautomeric equilibrium with their "hydrazone form" 12; in alkaline medium, the equilibrium is entirely shifted to the "Hydrazone salt form" 13.
28 citations
TL;DR: The paper describes the synthesis and antimicrobial activity of some classical hydrazones of benzophenones and of 1,2-diketones and N-(Diaryl) acyl derivatives of these hydrazone have been synthesized and evaluated.
Abstract: The paper describes the synthesis and antimicrobial (antileishmanial, antibacterial and antifungal) activity of some classical hydrazones of benzophenones and of 1,2-diketones. N-(Diaryl) acyl derivatives of these hydrazones have also been synthesized and evaluated. 4,4,-Demthoxybenzil monohydrazone and 4,4′-dimethoxybenzophenone hydrazone showed significant antileishmanial activity. The effect of substituents on the bioactivity is discussed.
28 citations