Topic
Hydrazone
About: Hydrazone is a research topic. Over the lifetime, 4853 publications have been published within this topic receiving 65160 citations. The topic is also known as: hydrazone.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: In this paper, the copper(II) complexes with DMSO adducts, [Cu(L1)(DMSO)] and [C2·5H2O], were prepared by the stoichiometric reaction of the CuCl2·1·5 H2O with the H 2L1 and H2L2H2 in a molar ratio (M:L) of 1:1 in a mixture of water mixture, and the results from antioxidant assays have shown that both ligands have excellent activities.
26 citations
••
TL;DR: It has been shown that the complexes induce apoptosis in the caspase 3-dependent manner, whereas the anti-angiogenic effects of 1, 2, and 3 have been confirmed in EA.
26 citations
••
26 citations
••
TL;DR: A novel series of phenyl hydrazone bearing pyrazole and pyrimidine hybrid compounds designed using the molinspiration toolkit based on Lipinski's rule of five showed a potent anti-HIV activity along with a prominent inhibition of bacterial organisms.
Abstract: A novel series of phenyl hydrazone bearing pyrazole and pyrimidine hybrid compounds has been designed using the molinspiration toolkit based on Lipinski's rule of five and developed via sequential reactions starting from the diazotization of different anilines and further active methylation with acetyl acetone, ethyl acetoacetate and ethyl cyanoacetate to generate hydrazono derivatives. The target hybrid compounds were synthesized on cyclisation of the resulting hydrazono derivatives with hydrazine, phenyl hydrazine and urea. These molecules have been subsequently tested for anti-HIV activity using TZM-bl cell lines. The MTT assay was also carried out for the cytotoxicity determination of the active compounds. Further, to exemplify the key structural features of the molecules, a molecular docking analysis of the most active compounds was performed at the NNIBP of the HIV-RT protein. The antibacterial activity of the target compounds was also determined against a panel of four Gram-positive and four Gram-negative human pathogens. All molecules showed a potent anti-HIV activity along with a prominent inhibition of bacterial organisms.
26 citations