Topic
Hydrazone
About: Hydrazone is a research topic. Over the lifetime, 4853 publications have been published within this topic receiving 65160 citations. The topic is also known as: hydrazone.
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23 citations
TL;DR: Palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenyl-2-propenyl acetate (4 ) with a dimethyl malonate-BSA-LiOAc system has been successfully carried out in the presence of chiral phosphine-hydrazone ligands such as 3a in good yields with good enantioselectivities as discussed by the authors.
23 citations
TL;DR: The asymmetric synthesis of the lichen macrolide (+)-aspicilin (1) was realised in 19 steps and with high stereoselectivity (de ≥ 91 %, ee ≥ 96%) by employing the SAMP/RAMP hydrazone method.
Abstract: The asymmetric synthesis of the lichen macrolide (+)-aspicilin (1) was realised in 19 steps and with high stereoselectivity (de ≥ 91 %, ee ≥ 96%). Three of the four stereogenic centres were generated by employing the SAMP/RAMP hydrazone method. Key steps of the synthesis are the α,α′-double alkylation of RAMP hydrazone (R)-10 of 2,2-dimethyl-1,3-dioxan-5-one B and the enantioselective synthesis of the bromo alcohol (S)-9 (subunit A) by a combination of SAMP hydrazone α-alkylation with subsequent Baeyer-Villiger oxidation.
23 citations
TL;DR: In this paper, the reaction of ethyl arylhydrazonochloroacetates (1) with 2-aminothiophenol (2) in ethanol in the presence of triethylamine yielded the respective 1,4-benzothiazine derivatives 4.
23 citations
TL;DR: A series of guanylhydrazone, amidine, and hydrazone derivatives of 2-phenylimidazo[1,2-a]pyridine have been prepared and evaluated for macrofilarial activity against Acanthocheilonema viteae and Brugia pahangi in jirds.
Abstract: A series of guanylhydrazone, amidine, and hydrazone derivatives of 2-phenylimidazo[1,2-a]pyridine have been prepared and evaluated for macrofilarial activity against Acanthocheilonema viteae and Brugia pahangi in jirds. Compounds with 4‘,6-bis-substitution by cyclic guanylhydrazone groups show activity. 4‘,6-Bis-amidines show some activity but are more toxic; 4‘- or 6-monosubstituted compounds are inactive. 2,6-Bis-substituted compounds lacking the phenyl ring are inactive. 4‘,6-Bis-substituted compounds having additional double bonds inserted between the heterocyclic ring and the phenyl ring or between the substituent and the ring system show reduced activity.
23 citations