Topic
Hydrazone
About: Hydrazone is a research topic. Over the lifetime, 4853 publications have been published within this topic receiving 65160 citations. The topic is also known as: hydrazone.
Papers published on a yearly basis
Papers
More filters
TL;DR: Two new copper(I) hydrazone complexes have been synthesised from bivalent copper precursor [CuCl(2)(PPh(3))(2)] and ferrocene containing bidentate hydraz one ligands HL(1) or HL(2) (2) based on the elemental analyses and spectroscopic data.
Abstract: Two new copper(I) hydrazone complexes have been synthesised from bivalent copper precursor [CuCl2(PPh3)2] and ferrocene containing bidentate hydrazone ligands HL1 (1) or HL2 (2). Based on the elemental analyses and spectroscopic data, the complexes are best formulated as [CuL1(PPh3)2] (3) and [CuL2(PPh3)2] (4) of the monovalent copper ion. Solid state structures of ligand 2 and its corresponding complex 4 were also determined. The DNA/albumin interactions of all the synthesised compounds were investigated using absorption, emission and synchronous fluorescence studies. Further, antioxidant properties of all the compounds have also been checked against ABTS, O2− and OH radicals. Additionally, the in vitro cytotoxic activity of compounds 1–4 was assessed using tumour (HeLa, A431) and non-tumour (NIH 3T3) cell lines.
93 citations
TL;DR: In this article, the Ramaman spectra of a number of azo dye structures have been analyzed in aqueous basic and acidic media, and it was noted that the azo-anions (examined at pH 12) convert to the protonated neutral hydrazone (keto) form.
Abstract: Raman spectra of a number of azo dye structures have been analyzed. In azonaphthol and azopyrazol dyes, hydroxyazo to ketohydrazone tautomerizations, —N=N—C=C—OH →← —HN—N=C—C=O were observed in aqueous basic and acidic media. Observations of azo and ring vibrations, as well as hydrazone (C=N plus C=O) bands, were made. It was noted that the azo-anions (examined at pH 12) convert to the protonated neutral hydrazone (keto) form in aqueous acid (run at pH 2). Infrared spectra were used to confirm the presence of the C=O group in keto-tautomeric forms.
93 citations
93 citations
TL;DR: The data suggest that nickel transport is not dependent on the membrane potential or on intracellular ATP, but is coupled to proton movement.
Abstract: Methanobacterium bryantii, grown autotrophically on H2-CO2, transported nickel against a concentration gradient by a high-affinity system (Km = 3.1 microM). The system had a pH optimum of 4.9 and a temperature optimum of 49 degrees C with an energy of activation of 7.8 kcal/mol (ca. 32.6 kJ/mol). A headspace of H2-CO2 (4:1, vol/vol) was required for maximum rate of transport. The system was highly specific for nickel and was unaffected by high levels of all monovalent and divalent ions tested (including Mg2+) with the sole exception of Co2+. Kinetic experiments indicated that accumulated nickel became increasingly incorporated into cofactor F430 and protein. Nickel transport was inhibited by nigericin, monensin, and gramicidin but not by carbonyl cyanide-p-trifluoromethoxyphenyl hydrazone, carbonyl cyanide-m-chlorophenyl hydrazone, N,N'-dicyclohexylcarbodiimide, valinomycin plus potassium, or acetylene. The ineffectiveness of carbonyl cyanide-p-trifluoromethoxyphenyl hydrazone, carbonyl cyanide-m-chlorophenyl hydrazone, and N,N'-dicyclohexylcarbodiimide may be related to difficulties in the penetration of these compounds through the outer cell barriers. Nickel uptake was greatly stimulated by an artificially imposed pH gradient (inside alkaline). The data suggest that nickel transport is not dependent on the membrane potential or on intracellular ATP, but is coupled to proton movement.
93 citations
TL;DR: A series of potential anti-oxidant and anti-bacterial N'-arylmethylidene-2-(3,4-dimethyl-5,5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-2(4H)-yl)acetohydrazides was synthesized in a facile way starting from commercially available saccharine.
92 citations