Topic
Hydrazone
About: Hydrazone is a research topic. Over the lifetime, 4853 publications have been published within this topic receiving 65160 citations. The topic is also known as: hydrazone.
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TL;DR: The results showed clearly that compounds 4, 5, 13, 22, and 24 displayed promising in vitro anticancer activity against four different cell lines (HepG2, WI 38, VERO and MCF-7).
84 citations
TL;DR: New hydrazone derivatives were synthesized via the nucleophilic addition-elimination reaction of 2-[(1-methyl-1H-tetrazol-5-yl)thio)]acetohydrazide with aromatic aldehydes/ketones and can be identified as the most promising anticancer agent against A549 cancer cell lines due to its inhibitory effect on A549 cell lines and low toxicity to NIH3T3 cells.
84 citations
TL;DR: In this paper, the formation constants for the iron(III) complexes of the orally effective iron chelator pyridoxal isonicotinoyl hydrazone (PIH) and three analogues were determined by a combination of spectrophotometry and potentiometry.
84 citations
TL;DR: A thin and well-defined film of covalently attached benzaldehyde with an estimated coverage of 4 x 10(-10) mol cm(-2) was formed and the electrochemical responses of benzaldehyde were highly reproducible and largely independent of grafting medium and along with that also the thickness of the initially grafted film.
Abstract: A methodology is described for introducing a thin layer of covalently attached benzaldehyde on glassy carbon surfaces using aryl diazonium chemistry. Usually the electroreduction of aryl diazonium salts leads to the formation of an ill-defined multilayer because of the involvement of highly reactive aryl radicals that can add to already-grafted aryl groups. However, in this study we used a two-step “formation-degradation” procedure to solve this problem with the first step consisting of an electrografting of an aryl diazonium salt of a long-chain and bulky alkyl hydrazone onto a glassy carbon surface. The design of the hydrazone group serves to minimize multilayer formation by greatly diminishing the grafting rate after the first-layer formation and at the same time preventing radical additions from taking place at the inner aryl ring. Another valuable property of the hydrazone group is that it easily can be deprotected to the corresponding aldehyde by acid hydrolysis (i.e., the degradation step). In this...
84 citations
TL;DR: A palladium-catalyzed Heck-type cascade reaction of aryl halides and N-tosyl hydrazones is reported and the neopentylpalladium species could efficiently react with carbenes to form highly functionalized alkenes.
84 citations