Topic
Hydrazone
About: Hydrazone is a research topic. Over the lifetime, 4853 publications have been published within this topic receiving 65160 citations. The topic is also known as: hydrazone.
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TL;DR: A serendipitous discovery has led to a new hydrazone-based low molecular weight fluorescent super-hydrogelator that can be switched "ON" and "OFF" using pH, enabling the sensing of biogenic amines emanating from spoiled cod.
68 citations
TL;DR: In this article, the thermal stability of a given oxadiazoline and what products were formed by its thermal decomposition were found to depend on the natures of the substituents at C-2.
Abstract: The electrolytic oxidation of ketone N-acylhydrazones (1) in methanolic sodium acetate induced their intramolecular cyclization to the corresponding 2-methoxy-Δ 3 -1,3,4-oxadiazolines 3. The thermal stability of a given oxadiazoline and what products were formed by its thermal decomposition was found to depend on the natures of the substituents at C-2. Thus, 2-methoxy-2-phenyloxadiazolines preferentially yielded oxiranes 5, whereas 2-alkyl-2-methoxyoxazolines preferentially gave enol ethers 6
68 citations
TL;DR: In this paper, aldimine and hydrazone isoquinoline derivatives were obtained after subjecting 1-formyl-5-nitroisoquinoline to classical reactions.
68 citations
TL;DR: The hydrazone derivative 15(d) (1-[4-methoxybenzyl)-6-methylphenyl pyridazin-3(2H)-ylidene]-2-(2-carboxydiphenyl methyl) hydrazine) showed the highest biological activity.
68 citations
TL;DR: It is suggested that the complexes act as lipophilic transport shuttles that allow entrance to the cell and enable the delivery of both the ligand and metal which act in concert to inhibit proliferation.
Abstract: In an effort to better understand the antiproliferative effects of the tridentate hydrazone chelators di-2-pyridyl ketone isonicotinoyl hydrazone (HPKIH) and di-2-pyridyl ketone benzoyl hydrazone (HPKBH), we report the coordination chemistry of these ligands with the divalent metal ions, Mn, Co, Ni, Cu, and Zn. These complexes are compared with their FeII analogues which were reported previously. The crystal structures of Co(PKIH)2, Ni(PKIH)2, Cu(PKIH)2, Mn(PKBH)2, Ni(PKBH)2, Cu(PKBH)2, and Zn(PKBH)2 are reported where similar bis-tridenate coordination modes of the ligands are defined. In pure DMF, all complexes except the ZnII compounds exhibit metal-centered MIII/II (Mn, Fe, Co, Ni) or MII/I (Cu) redox processes. All complexes show ligand-centered reductions at low potential. Electrochemistry in a mixed water/DMF solvent only elicited metal-centered responses from the Co and Fe complexes. Remarkably, all complexes show antiproliferative activity against the SK-N-MC neuroepithelioma cell line similar to...
68 citations