Topic
Hydrazone
About: Hydrazone is a research topic. Over the lifetime, 4853 publications have been published within this topic receiving 65160 citations. The topic is also known as: hydrazone.
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TL;DR: In this article, a series of octahedral and square-planar Ni(II) complexes have been synthesized from two different types of hydrazone ligands, and the isolated complexes were characterized by means of analytical and spectroscopic techniques.
62 citations
TL;DR: The design, synthesis and evaluation of novel thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as cyclin-dependent kinase 4 (CDK4) inhibitor are described.
62 citations
TL;DR: Trichloroacetaldehyde tosylhydrazone acts as an excellent precursor of diazodithioacetate which is generated by treatment of the hydrazone with sulfide ion as mentioned in this paper.
Abstract: Trichloroacetaldehyde tosylhydrazone acts as an excellent precursor of diazodithioacetate which is generated by treatment of the hydrazone with sulfide ion. This spontaneously cyclizes it to 5-mercapto-1,2,3-thiadiazole. The precursor also gives a 5-amino-1,2,3-triazole on reaction with an amine. α,α-Dichloro ketone tosylhydrazones similarly cyclize to give 1,2,3-thiadiazoles and 1,2,3-triazoles.
62 citations
TL;DR: This work developed a method of rapid and tunable Z→E isomerization of C=N bond in acyl hydrazones, using aromatic thiols as nucleophilic catalysts, and has applied this method to control the diversity of acylhydrazone based dynamic combinatorial libraries.
Abstract: Photoisomerization provides a clean and efficient way of reversibly altering physical properties of chemical systems and injecting energy into them. These effects have been applied in development of systems such as photoresponsive materials, molecular motors, and photoactivated drugs. Typically, switching from more to less stable isomer(s) is performed by irradiation with UV or visible light, while the reverse process proceeds thermally or by irradiation using another wavelength. In this work we developed a method of rapid and tunable Z→E isomerization of C═N bond in acyl hydrazones, using aromatic thiols as nucleophilic catalysts. As thiols can be oxidized into catalytically inactive disulfides, the isomerization rates can be controlled via the oxidation state of the catalyst, which, together with the UV irradiation, provides orthogonal means to control the E/Z state of the system. As a proof of this concept, we have applied this method to control the diversity of acyl hydrazone based dynamic combinatori...
62 citations
TL;DR: New series of Schiff’s bases, hydrazones, thiosemicarbazone derivatives, thiazoles, and thiocarbohydrazones of 5-fluoroisatin were synthesized by the reaction of primary amines,Hydrazine hydrate, andThiocarbohydrazides and exhibited antiviral activity.
Abstract: New series of Schiff’s bases, hydrazones, thiosemicarbazones, thiazoles, and thiocarbohydrazones of 5-fluoroisatin were synthesized by the reaction of 5-fluoroisatin with primary amines, hydrazine hydrate, and thiocarbohydrazides. Thiosemicarbazones were prepared by reacting hydrazone derivatives with isothiocyanates. Upon treatment of thiosemicarbazone derivatives with chloroacetone, the thiazole derivatives were obtained. Some of the prepared compounds exhibited antiviral activity.
61 citations