Topic
Hydrazone
About: Hydrazone is a research topic. Over the lifetime, 4853 publications have been published within this topic receiving 65160 citations. The topic is also known as: hydrazone.
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TL;DR: In this article, four new azo dyes were prepared by linking benzaldehyde p-aminobenzoylhydrazone (3) and p-hydroxybenzaldehyede (4) to barbituric acid and 1,3-dimethylbarbiturric acid through diazo-coupling reactions.
Abstract: Four new azo dyes, L, L, L, and L, were prepared by linking benzaldehyde p-aminobenzoylhydrazone (3) and p-hydroxybenzaldehyede p–aminobenzoylhydrazone (4) to barbituric acid and 1,3-dimethylbarbituric acid through diazo-coupling reactions. Reactions of the azo-dyes with copper chloride and bidentate ligand, 1,10-phenanthroline, produced mixed-ligand dinuclear complexes with general stoichiometry [Cu2L(phen)2 ]Cl2 (7, 8, 9, and 10). The structures of both azo dyes and their complexes were identified by elemental analyses, FT-IR, H-NMR, UV-VIS, magnetic susceptibility, and mass spectral data.
59 citations
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TL;DR: In this article, the salicylidene 2-picoloyl hydrazone ligand (H2sal-phz) was prepared by reaction of picoloyls hydrazine with Salicylaldehyde, and the new compounds were characterized by 1H NMR and IR spectroscopies.
59 citations
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TL;DR: A palladium-catalyzed C(sp(2))-H difluoromethylation of aldehyde-derived hydrazones using bromodifluolorometHylated compounds to afford the corresponding functionalized diffluorometrichylketonehydrazones has been established and it is proposed that a radical/SET mechanism proceeding via a dif fluoroalkyl radical may be involved in the catalytic cycle.
Abstract: A palladium-catalyzed C(sp2)−H difluoromethylation of aldehyde-derived hydrazones using bromodifluoromethylated compounds to afford the corresponding functionalized difluoromethylketone hydrazones has been established. It is proposed that a radical/SET mechanism proceeding via a difluoroalkyl radical may be involved in the catalytic cycle. Applications of the methodology to the synthesis of α,α-difluoro-β-ketoesters and α,α-difluoroketones (RCOCF2H) have been illustrated.
59 citations
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01 Jan 1989TL;DR: The chelation of zinc(II) for all the ligands studied was greater than that for calcium (II) and magnesium(II), with complexation generally becoming significant at about pH 5.4.
Abstract: Formation constants for the calcium(II), magnesium(II) and zinc(II) complexes of the orally effective iron chelator, pyridoxal isonicotinoyl hydrazone (PIH) and three analogues, pyridoxal benzoyl hydrazone (PBH), pyridoxalp-methoxybenzoyl hydrazone (PpMBH) and pyridoxalm-fluorobenzoyl hydrazone (PmFBH) have been determined by potentiometry at 25\dg C andI=0.1 M [KNO3]. The four ligands bind calcium(II) weakly and magnesium(II) only slightly more strongly, as a l: l complex which is formed at pH \s> 8. The chelation of zinc(II) for all the ligands studied was greater than that for calcium(II) and magnesium(II), with complexation generally becoming significant at about pH 5. Thus, chelation of zinc(II) but not calcium(II) or magnesium(II) at physiological pH, 7.4 may be expected. Calculated values of the concentration of uncomplexed metal ion indicate that the selectivity of these ligands towards Fe(III) is comparable to that of the clinically used chelator desferrioxamine.
59 citations
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TL;DR: Palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenyl-2-propenyl acetate with a dimethyl malonate-BSA-LiOAc system and its derivatives has been successfully carried out in the presence of a new chiral hydrazone ligands in high yields with high enantioselectives.
Abstract: Palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenyl-2-propenyl acetate (4) with a dimethyl malonate−BSA−LiOAc system and its derivatives has been successfully carried out in the presence of a new chiral hydrazone ligands such as 2-(diphenylphosphino)benzaldehyde SAMP hydrazone (DPPBA-SAMP) (3a) in high yields with high enantioselectives.
59 citations