Topic
Hydrazone
About: Hydrazone is a research topic. Over the lifetime, 4853 publications have been published within this topic receiving 65160 citations. The topic is also known as: hydrazone.
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50 citations
TL;DR: It is noteworthy that the addition of N,N-ligands to the copper(II) complex lead to the enhancement in the cytotoxicity of the compounds, especially against human prostate adenocarcinoma cell line (PC-3).
50 citations
TL;DR: In this article, a 1,8-naphthalimide hydrazone derivative bearing a pyrrole unit is used to monitor intracellular Cu 2+ in HeLa cells.
Abstract: A 1,8-naphthalimide hydrazone derivative bearing a pyrrole unit is a highly selective ratiometric fluorescent Cu 2+ probe used to monitor intracellular Cu 2+ in HeLa cells. This probe functions via a unique hydrolysis mechanism through Cu 2+ -promoted electrophilic substitution. Binding is confirmed through UV–vis absorption, fluorescence measurements, mass spectroscopy, IR, X-ray single crystal diffraction, and DFT calculation.
50 citations
TL;DR: Phosphine-free hydrazone such as 1c was found to be an efficient ligand for the copper-catalyzed Goldberg-type and Ullmann-type N-arylation of amides and azoles with aryl halides under mild conditions.
Abstract: Phosphine-free hydrazone such as 1c was found to be an efficient ligand for the copper-catalyzed Goldberg-type N-arylation of amides and Ullmann-type N-arylation of azoles with aryl halides under mild conditions. A variety of N-arylamides and N-arylazoles were synthesized in good to high yields.
50 citations
TL;DR: Hydrazone derivatives synthesized via the reaction of 3-cyclohexylpropionic acid hydrazide with various benzaldehydes suggest that different functional groups on the phenyl ring influence the physicochemical properties and thus modulate biological activity.
Abstract: In the present study, some hydrazone derivatives were synthesized via the reaction of 3-cyclohexylpropionic acid hydrazide with various benzaldehydes. The chemical structures of the compounds were elucidated by spectroscopic techniques such as IR, 1 H-NMR and FAB-MS and elemental analyses. The compounds were evaluated for their anti- inflammatory and cytotoxic activities. Anti-inflammatory activity was determined in terms of inhibition of NF-! B, ROS generation and iNOS activity. Several derivatives inhibited NF-! B and iNOS, but no effect was observed on intracellular ROS generation. Furthermore no cytoxicity was observed. Biological activity compared with the chemical structural information suggests that different functional groups on the phenyl ring influence the physicochemical properties and thus modulate biological activity.
50 citations