Topic
Hydrazone
About: Hydrazone is a research topic. Over the lifetime, 4853 publications have been published within this topic receiving 65160 citations. The topic is also known as: hydrazone.
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TL;DR: In this article, three new mixed ligand hydrazone complexes viz., [Cu(L)(neocuprin)]NO3·H2O 1, [Cu (L)(HL)]ClO4 2 and [Cu2(2-(2-pyridyl)benzimidazole)2(L)2]CLO4 3 (L = N′-[(E)-phenyl(pyrin-2-yl)methylidene]furan-2 carbohydrazide) have been synthesized by the biomimetic
46 citations
TL;DR: 2-(6,8-Dibromo-2-methylquinazolin-4-yloxy)-acetohydrazide was prepared by the reaction of formamide with formamide to afford quinazolinone 2 and alkylation with ethyl chloroacetate to give the ester.
Abstract: 2-(6,8-Dibromo-2-methylquinazolin-4-yloxy)-acetohydrazide (4) was prepared by the reaction of 6,8-dibromo-2-methylbenzo-[d][1,3]oxazin-4-one with formamide to afford quinazolinone 2, followed by alkylation with ethyl chloroacetate to give the ester 3. Treatment of ester 3 with hydrazine hydrate and benzaldehyde afforded 4 and styryl quinazoline 5. The hydrazide was reacted with triethyl orthoformate, acetylacetone and ethyl acetoacetate and benzaldehyde derivatives to afford the corresponding pyrazoles 6, 7, 9 and hydrazone derivatives 10a-c. Cyclization of hydrazones 10a-c with thioglycolic acid afforded the thiazole derivatives 11a-c. Reaction of the hydrazide with isothiocyanate derivatives afforded hydrazinecarbothioamide derivatives 12a-c, which cyclized to triazole-3-thiols and thiadiazoles 13a-c and 14a-c, respectively. Fusion of the hydrazide with phthalimide afforded the annelated compound 1,2,4-triazolo[3,4-a]isoindol-5-one (15). The newly synthesized compounds were characterized by their spectral (IR, 1H-, 13C-NMR) data. Selected compounds were screened for analgesic activity.
46 citations
TL;DR: In this paper, the 13 C and 15 N-NMR spectra of compounds prepared by coupling benzenediazonium ions with 9-hydroxyanthracene, acetylcyclopentadiene, 8-hydroxy quino line, 3-cyano-1,4-dimethylpyridine-2,6-dione and 1-naphthol have been measured.
46 citations
TL;DR: In this article, a novel organic-inorganic hybrid heterogeneous catalyst system was obtained from the reaction of the molybdenum(VI) complex of salicylidene 2-picoloyl hydrazone with mesoporous silica containing 3-chloropropyl groups.
Abstract: A novel organic–inorganic hybrid heterogeneous catalyst system was obtained from the reaction of the molybdenum(VI) complex of salicylidene 2-picoloyl hydrazone with mesoporous silica containing 3-chloropropyl groups prepared by a direct synthetic approach involving hydrolysis and co-condensation of tetraethylorthosilicate (TEOS) and 3-chloropropyltrimethoxysilane in the presence of the triblock copolymer P123 as template under acidic conditions. Characterization of the functionalized materials by X-ray diffraction (XRD), high resolution transmission electron microscopy (HRTEM), scanning electron microscopy (SEM), N 2 adsorption/desorption, FT-IR and UV–Vis spectroscopy, and thermogravimetric analysis (TGA) reveals that the molybdenum complex is successfully grafted into the pores of the host silica structure. Furthermore, the resulting hybrid material was found to be highly active catalyst in the liquid-phase epoxidation of olefins with t -BuOOH as the oxygen source. Leaching tests and metal analysis of reaction solutions show that the catalytic activity stemmed from the immobilized species, not from the leaching of active species into solution.
46 citations
TL;DR: A hydrazone-based method for conjugating synthetic nucleic acids and reporter molecules for use as nonradioactive hybridization probes is presented and was able to detect 7 amol of target DNA in 1 h, using a colorimetric assay.
46 citations