Topic
Hydrazone
About: Hydrazone is a research topic. Over the lifetime, 4853 publications have been published within this topic receiving 65160 citations. The topic is also known as: hydrazone.
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TL;DR: This study identified several important design criteria for improvement of the antiproliferative selectivity of the aroylhydrazone iron chelators.
42 citations
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42 citations
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TL;DR: In vitro cytotoxic potential of the above ruthenium hydrazone complexes assayed against the A549 cell line revealed a significant growth inhibition and cell death induced by the complexes showed noticeable changes in the cell morphology which resembled apoptosis.
Abstract: A set each of new bivalent and trivalent ruthenium complexes, [RuIII(HL)Cl2(EPh3)2] and [RuII(L)(CO)(EPh3)2] (E = P (complexes 1 and 2) or As (complexes 3 and 4)) were synthesised from the reactions of [RuIIICl3(EPh3)3] with 2-hydroxynaphthaldehyde benzoic acid hydrazone (H2L) in methanol–chloroform and characterized by elemental analysis, spectral data and XRD study. A suitable mechanism to account for the formation of bivalent ruthenium carbonyl complexes from the corresponding trivalent precursors is provided by considering the role of added base in the reaction. Interaction of complexes 1–4 with CT-DNA/bovine serum albumin was analysed with absorption and emission spectral titration studies. In vitro cytotoxic potential of the above ruthenium hydrazone complexes 1–4 assayed against the A549 cell line revealed a significant growth inhibition. The test complexes 1–4 added in IC50 concentration into the cell culture medium enhanced the release of lactate dehydrogenase, NO and reactive oxygen species in comparison with the control. Cell death induced by the complexes was studied using a propidium iodide staining assay and showed noticeable changes in the cell morphology which resembled apoptosis.
42 citations
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TL;DR: In this paper, the quinoline hydrazone ligands were synthesized through multi-step reactions using Vilsmeier-Haack reaction and the molecular structures of the ligands (3a, 3i) and the Zn complexes were characterized by elemental analysis and spectral studies like FT-IR, 1 H and 13 C NMR, MS, UV-Visible and fluorescence.
42 citations
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TL;DR: Aryllithium reagents were used in Fischer indole synthesis as mentioned in this paper, where the aryl hydrazones were converted into indoles in good yields by heating with thionyl chloride in alcohol.
41 citations