Topic
Hydrazone
About: Hydrazone is a research topic. Over the lifetime, 4853 publications have been published within this topic receiving 65160 citations. The topic is also known as: hydrazone.
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TL;DR: An efficient palladium-catalyzed asymmetric synthesis of axially chiral vinyl arenes from aryl bromides and hydrazones is reported.
Abstract: An efficient palladium-catalyzed asymmetric synthesis of axially chiral vinyl arenes from aryl bromides and hydrazones is reported. The products were easily oxidized to axially chiral biaryl compounds, and the phosphine oxides were readily reduced to phosphine ligands.
138 citations
TL;DR: Gaby et al. as discussed by the authors showed that the synthesis of 4-benzoyl-1,2-phenylenediamine with sodium pyruvate in acetic acid provided two products which were identified as 6-benzinoyl and 7-benenzoyl 3-methyl-2(1H)quinoxalinones (1a,b ).
Abstract: Department of Chemistry, Faculty of Science, Al-Azhar University at Assiut, Assiut 71524, EgyptFax: 002(088)325436, E-mail: m_elgaby@hotmail.comReceived: 29 April 2000 / Accepted: 13 June 2000 / Published: 18 June 2000Abstract: Condensation of 4-benzoyl-1,2-phenylenediamine with sodium pyruvate in aceticacid furnished two products which were identified as 6-benzoyl and 7-benzoyl-3-methyl-2(1H)quinoxalinones ( 1a ,b ). Fusion of 1a with aromatic aldehydes furnished the styryl de-rivatives 2a -c. Alkylation of 1a ,b with dimethyl sulphate or ethyl chloroacetate produced theN-alkyl derivatives 3a ,b and 4a ,b . Hydrazinolysis of the ester derivative 4a with hydrazinehydrate afforded the hydrazide derivative 5 which underwent condensation with aldehydes togive the corresponding hydrazone derivatives 6a ,b . In addition, chlorination of 1a withthionyl chloride afforded the 2-chloro derivative 7 which was subjected to reaction with s o-dium azide and n-butylamine to yield the corresponding tetrazolo (8) and n-butylamino (9)derivatives, respectively. The structures of the compounds prepared were confirmed by an a-lytical and spectral data. Also, some of the synthesized compounds were screened for antim i-crobial activity.Keywords: Quinoxalinones, 4-benzoyl-1,2-phenylenediamine, antimicrobial activity.
137 citations
TL;DR: The method has been applied for the determination of hydrazine in boiler feed water and the resulting yellow colored product is stable in acidic medium and has a maximum absorption at 458 nm.
135 citations
TL;DR: Kinetics studies with structurally varied aldehydes and ketones in aqueous buffer at pH 7.4 reveal that carbonyl compounds with neighboring acid/base groups form hydrazones at accelerated rates.
Abstract: Kinetics studies with structurally varied aldehydes and ketones in aqueous buffer at pH 7.4 reveal that carbonyl compounds with neighboring acid/base groups form hydrazones at accelerated rates. Similarly, tests of a hydrazine with a neighboring carboxylic acid group show that it also reacts at an accelerated rate. Rate constants for the fastest carbonyl/hydrazine combinations are 2-20 M(-1) s(-1), which is faster than recent strain-promoted cycloaddition reactions.
134 citations
TL;DR: A series of novel 3-aryl-1-(4- tert -butylbenzyl) -1 H -pyrazole-5-carbohydrazide hydrazone derivatives were synthesized and the effects of all the compounds on A549 cell growth were investigated as mentioned in this paper.
133 citations