Hydrazone

About: Hydrazone is a research topic. Over the lifetime, 4853 publications have been published within this topic receiving 65160 citations. The topic is also known as: hydrazone.

Nickel and cobalt complexes of benzoic acid (2-hydroxy-benzylidene)-hydrazide ligand: synthesis, structure and comparative in vitro evaluations of biological perspectives

Abstract: Reactions of tridentate chelating hydrazone Schiff bases benzoic acid (2-hydroxyl-benzylidene)-hydrazide (H2L) (1) obtained from salicylaldehyde and benzhydrazide with [NiCl2(PPh3)2] and [CoCl2(PPh3)2] afforded respective metal hydrazone complexes of the composition [Ni(L)(PPh3)] (2) and [Co1(L)2]2[Co2(H2O)4(OPPh3)2] (3). The molecular structure of both complexes 2 and 3 determined by single crystal X-ray diffraction revealed that complex 2 is neutral in charge with distorted square planar geometry. However, complex 3 was found to have distorted octahedral geometry. All of the synthesised compounds 1–3 were studied by interaction with calf thymus DNA (CT DNA) and bovine serum albumin (BSA). In addition in vitro free radical scavenging and cytotoxic potential of all the synthesised compounds were also investigated.

Synthesis, Characterization and Antibacterial Activity of Biologically Important Vanillin Related Hydrazone Derivatives

Abstract: Hydrazone derivatives of vanillin are found to possess anti-bacterial activities. Based on higher bio-activity of hydrazones, new hydrazone derivatives were synthesized from Piperdine-4-carboxylicacid methyl ester (1). The compounds 1-pyrimidine-2-yl piperidine-4-carboxylicacid(4-hydroxy-3-methoxy benzylidine)-hy- drazide (10), 1-pyrimidine-2-yl piperidine-4-carboxylicacid (3,4-dimethoxy benzylidine) hydrazide (11), 1-pyrimidine-2-yl piperidine-4-carboxylicacid(4-butoxy-3-methoxy benzylidine)-hydrazide (12), 1-pyr- imidine-2-yl piperidine-4-carboxylicacid(3-methoxy-4(2-methoxy ethoxy) benzylidine)-hydrazide (13) were synthesized, purified and characterized by 1HNMR, 13CNMR, LCMS, FT-IR and HPLC techniques. The synthesized hydrazone derivatives were further checked for anti-bacterial activities by paper disc diffusion method against Pseudomonas aeruginosa and Staphylococcus aureus bacterial strains.

Hole drift mobility and chemical structure of charge‐transporting hydrazone compounds

Abstract: The hole drift mobility of several hydrazone compounds dispersed in a polymer binder was correlated with their chemical structure. The mobility of hydrazone compounds having the same basic skeleton, i.e., aminophenylhydrazone, varied over about two orders of magnitude by systematic change of the substituents on the N atoms. The variety of the hole mobility was discussed on the basis of the concept of polyfunctionality and intramolecular mobility. From molecular orbital calculations, the importance of the positive charge distribution on a molecule in the cation radical state was emphasized for the molecular design of high‐mobility charge‐transporting compounds.

The ligational behavior of a phenolic quinolyl hydrazone towards copper(II)- ions

Abstract: The heterocyclic hydrazones constitute an important class of biologically active drug molecules. The hydrazones have also been used as herbicides, insecticides, nematocides, redenticides, and plant growth regulators as well as plasticizers and stabilizers for polymers. The importance of the phenolic quinolyl hydrazones arises from incorporating the quinoline ring with the phenolic compound; 2,4-dihydroxy benzaldehyde. Quinoline ring has therapeutic and biological activities whereas, phenols have antiseptic and disinfectants activities and are used in the preparation of dyes, bakelite and drugs. The present study is planned to check the effect of the counter anions on the type and geometry of the isolated copper(II)- complexes as well as the ligational behavior of the phenolic hydrazone; 4-[(2-(4,8-dimethylquinolin-2-yl)hydrazono)methyl] benzene-1,3-diol; (H2L). A phenolic quinolyl hydrazone (H2L) was allowed to react with various copper(II)- salts (Cl‾, Br‾, NO3‾, ClO4‾, AcO‾, SO42-). The reactions afforded dimeric complexes (ClO4‾, AcO‾ ), a binuclear complex (NO3‾ ) and mononuclear complexes (the others; Cl‾, Br‾, SO42-). The isolated copper(II)- complexes have octahedral, square pyramid and square planar geometries. Also, they reflect the strong coordinating ability of NO3‾, Cl‾, Br‾, AcO‾ and SO42- anions. Depending on the type of the anion, the ligand showed three different modes of bonding viz. (NN)0 for the mononuclear complexes (3, 4, 6), (NO)- with O- bridging for the dimeric complexes (1, 5) and a mixed mode [(NN)0 + (NO)- with O- bridging] for the binuclear nitrato- complex (2). The ligational behavior of the phenolic hydrazone (H2L) is highly affected by the type of the anion. The isolated copper(II)- complexes reflect the strong coordinating power of the SO42-, AcO‾, Br‾, Cl‾ and NO3‾ anions. Also, they reflect the structural diversity (octahedral, square pyramid and square planar) depending on the type of the counter anion.