Topic
Hydrazone
About: Hydrazone is a research topic. Over the lifetime, 4853 publications have been published within this topic receiving 65160 citations. The topic is also known as: hydrazone.
Papers published on a yearly basis
Papers
More filters
TL;DR: New sugar hydrazones incorporating furan and/or 1,3,4-thiadiazole ring systems were synthesized by reaction of the corresponding hydrazide with different aldose sugars and high activities were revealed by compounds 3, 12 and 14 with IC50 values near to that of the reference drug doxorubicin.
Abstract: New sugar hydrazones incorporating furan and/or 1,3,4-thiadiazole ring systems were synthesized by reaction of the corresponding hydrazide with different aldose sugars. Heterocyclization of the formed hydrazones afforded the derived acyclic nucleoside analogues possessing the 1,3,4-oxadiazoline as modified nucleobase via acetylation followed by the heterocyclization process. The anticancer activity of the synthesized compounds was studied against human liver carcinoma cell (HepG-2) and at human normal retina pigmented epithelium cells (RPE-1). High activities were revealed by compounds 3, 12 and 14 with IC50 values near to that of the reference drug doxorubicin.
38 citations
38 citations
TL;DR: A novel nickel-catalyzed cross-coupling reaction between aldehydes and aryl halides via hydrazone intermediates has been developed, merging the Wolff-Kishner reduction and the classical cross-Coupling reactions.
38 citations
TL;DR: In this paper , the treatment of Cr(III), Fe(III) and Cu(II) metal ions with aryl hydrazone ligand named (E)-4-(((diphenylmethylene)hydrazono)methyl)benzene-1,3-diol (DPHB) to afford four novel solid complexes with high yields.
38 citations
TL;DR: The oximes of 2-acylthioanisole derivatives may be conveniently converted into 1,2-benzisothiazoles by acetic anhydride in pyridine as discussed by the authors.
Abstract: The oximes of 2-acylthioanisole derivatives may be conveniently converted into 1,2-benzisothiazoles by acetic anhydride in pyridine. 3-(2-Methylthiophenyl)-1,2-benzisothiazole, prepared by this met...
38 citations