Hydrazone

About: Hydrazone is a research topic. Over the lifetime, 4853 publications have been published within this topic receiving 65160 citations. The topic is also known as: hydrazone.

A hypervalent iodide-initiated fragment coupling cascade of N-allylhydrazones.

Abstract: Allylic hydrazines react with aldehydes and alcohols to afford functionalized ether adducts.

Synthesis and antibacterial activity against ralstonia solanacearum for novel hydrazone derivatives containing a pyridine moiety

Abstract: Ralstonia solanacearum, one of the most important bacterial diseases on plants, is a devastating, soil-borne plant pathogen with a global distribution and an unusually wide host range. In order to discover new bioactive molecules and pesticides acting on tobacco bacterial wilt, we sought to combine the active structure of hydrazone and pyridine together to design and synthesize a series of novel hydrazone derivatives containing a pyridine moiety. A series of hydrazone derivatives containing a pyridine moiety were synthesized. Their structures were characterized by 1 H-NMR, 13 C-NMR, IR, and elemental analysis. The preliminary biological activity tests showed that compound 3e and 3g exhibited more than 80% activity against Ralstonia solanacearum at 500 mg/L, especially compound 3g displayed relatively good activity to reach 57.0% at 200 mg/L. A practical synthetic route to hydrazone derivatives containing a pyridine moiety by the reaction of intermediates 2 with different aldehydes in ethanol at room temperature using 2-chloronicotinic acid and 2-amino-5-chloro-3-methylbenzoic acid as start materials is presented. This study suggests that the hydrazone derivatives containing a substituted pyridine ring could inhibit the growth of Ralstonia solanacearum.

Syntheses, crystal structures, and catalytic properties of dioxomolybdenum(VI) complexes with hydrazone ligands

Abstract: Two new dioxomolybdenum(VI) complexes, [MoO2L1(CH3OH)] (1) and [MoO2L2(H2O)] (2), where L1 and L2 are dianionic form of N′-(2-hydroxy-3-methoxybenzylidene)-4methoxybenzohydrazide and N′-(2-hydroxy-3methoxybenzylidene)-2-hydroxybenzohydrazide, respectively, have been synthesized and structurally characterized by spectroscopic methods and single-crystal X-ray determination. The complexes are mononuclear molybdenum(VI) compounds. Mo in each complex is octahedral. The difference in the substituent groups in the benzohydrazides leads to coordination of different solvent molecules. Crystals of the complexes are stabilized by hydrogen bonds. The complexes are effective catalysts for sulfoxidation.

Diorganotin(IV) complexes with furan-2-carbohydrazone derivatives: synthesis, characterization, crystal structure and antibacterial activity

Abstract: Four new diorganotin(IV) complexes, R2SnL (L = La: R = Me 1, Ph 2; L = Lb: R = Me 3, and Ph 4), have been synthesized by reaction of hydrazone ONO donors, 5-bromo-2-hydroxybenzaldehyde furan-2-carbohydrazone (H2La) and 2-hydroxynaphthaldehyde furan-2-carbohydrazone (H2Lb) with diorganotin(IV) dichloride in the presence of a base. The compounds have been investigated by elemental analysis and IR, 1H NMR, and 119Sn NMR spectroscopies. Spectroscopic studies show that the hydrazone is a tridentate dianionic ligand, coordinating via the imine nitrogen and phenolic and enolic oxygens. The structures of H2Lb and 3 have also been confirmed by X-ray crystallography. The results show that the structure of 3 is a distorted square pyramid with imine nitrogen in apical position. The in vitro antibacterial activities of ligands and complexes have been evaluated against gram-positive (Bacillus cereus and Staphylococcus aureus) and gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria. H2La and H2Lb show n...