Topic
Hydrazone
About: Hydrazone is a research topic. Over the lifetime, 4853 publications have been published within this topic receiving 65160 citations. The topic is also known as: hydrazone.
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TL;DR: Investigation of the utility of Nallylhydrazides as versatile chemical intermediates that allow for high yielding fragment coupling by way of hydrazone formation followed by a carbon–carbon bond-forming molecular rearrangement finds a “traceless” bond construction between two fragments.
Abstract: Allylic hydrazines react with aldehydes and alcohols to afford functionalized ether adducts.
37 citations
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TL;DR: In this article, the stereospecificity and orientation observed for the addition reaction of acetaldehyde hydrazone with (E)- and (Z)-alkenes in acidic media are compatible with a concerted process of the polar [3 + + 2] cycloaddition type.
37 citations
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TL;DR: This study suggests that the hydrazone derivatives containing a substituted pyridine ring could inhibit the growth of Ralstonia solanacearum.
Abstract: Ralstonia solanacearum, one of the most important bacterial diseases on plants, is a devastating, soil-borne plant pathogen with a global distribution and an unusually wide host range. In order to discover new bioactive molecules and pesticides acting on tobacco bacterial wilt, we sought to combine the active structure of hydrazone and pyridine together to design and synthesize a series of novel hydrazone derivatives containing a pyridine moiety. A series of hydrazone derivatives containing a pyridine moiety were synthesized. Their structures were characterized by 1 H-NMR, 13 C-NMR, IR, and elemental analysis. The preliminary biological activity tests showed that compound 3e and 3g exhibited more than 80% activity against Ralstonia solanacearum at 500 mg/L, especially compound 3g displayed relatively good activity to reach 57.0% at 200 mg/L. A practical synthetic route to hydrazone derivatives containing a pyridine moiety by the reaction of intermediates 2 with different aldehydes in ethanol at room temperature using 2-chloronicotinic acid and 2-amino-5-chloro-3-methylbenzoic acid as start materials is presented. This study suggests that the hydrazone derivatives containing a substituted pyridine ring could inhibit the growth of Ralstonia solanacearum.
37 citations
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TL;DR: In this article, two dioxomolybdenum(VI) complexes, [MoO2L1(CH3OH)] (1), where L1 and L2 are dianionic form of N′-(2-hydroxy-3-methoxybenzylidene)-4methoxidebenzohydrazide and N′-hydroxyl-3methoxylidenes)-2.hydroxybenzhydrazide, respectively, have been synthesized and structurally characterized by spectroscopic methods and single-cry
Abstract: Two new dioxomolybdenum(VI) complexes, [MoO2L1(CH3OH)] (1) and [MoO2L2(H2O)] (2), where L1 and L2 are dianionic form of N′-(2-hydroxy-3-methoxybenzylidene)-4methoxybenzohydrazide and N′-(2-hydroxy-3methoxybenzylidene)-2-hydroxybenzohydrazide, respectively, have been synthesized and structurally characterized by spectroscopic methods and single-crystal X-ray determination. The complexes are mononuclear molybdenum(VI) compounds. Mo in each complex is octahedral. The difference in the substituent groups in the benzohydrazides leads to coordination of different solvent molecules. Crystals of the complexes are stabilized by hydrogen bonds. The complexes are effective catalysts for sulfoxidation.
37 citations
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TL;DR: In this paper, four new diorganotin(IV) complexes were synthesized by reaction of hydrazone ONO donors, 5-bromo-2-hydroxybenzaldehyde furan-2 carbohydrazone (H2La), 2-hydroxynaphthaldehyde (2H2Lb), 2H2Nb and 3H2NB.
Abstract: Four new diorganotin(IV) complexes, R2SnL (L = La: R = Me 1, Ph 2; L = Lb: R = Me 3, and Ph 4), have been synthesized by reaction of hydrazone ONO donors, 5-bromo-2-hydroxybenzaldehyde furan-2-carbohydrazone (H2La) and 2-hydroxynaphthaldehyde furan-2-carbohydrazone (H2Lb) with diorganotin(IV) dichloride in the presence of a base. The compounds have been investigated by elemental analysis and IR, 1H NMR, and 119Sn NMR spectroscopies. Spectroscopic studies show that the hydrazone is a tridentate dianionic ligand, coordinating via the imine nitrogen and phenolic and enolic oxygens. The structures of H2Lb and 3 have also been confirmed by X-ray crystallography. The results show that the structure of 3 is a distorted square pyramid with imine nitrogen in apical position. The in vitro antibacterial activities of ligands and complexes have been evaluated against gram-positive (Bacillus cereus and Staphylococcus aureus) and gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria. H2La and H2Lb show n...
37 citations