Topic
Hydrogen peroxide
About: Hydrogen peroxide is a research topic. Over the lifetime, 42583 publications have been published within this topic receiving 1043732 citations. The topic is also known as: H2O2 & dioxidane.
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TL;DR: The aim of this study was to examine the catalyzed decomposition of hydrogen peroxide and 2-chlorophenol in the presence of iron oxides and granular ferrihydrite, goethite, and hematite were selected as catalysts.
259 citations
TL;DR: Mitochondria from beef heart, Morris hepatoma 3924A and Ehrlich ascites tumor and Lettré mutant have been studied with respect to hydrogen peroxidase and superoxide radical formation and the presence of superoxide dismutase activity, appearing to be precursors of hydrogen peroxide formation.
259 citations
TL;DR: It is concluded that isolated human plasma from healthy subjects is very unlikely to contain hydrogen peroxide in concentrations greater than about 0.25 microM and does not contain lipid hydroperoxides in concentrations less than 0.03 microM.
258 citations
TL;DR: In this article, the degradation of the model pollutant phenol with hydroxyl radicals generated from zero-valent iron and hydrogen peroxide has been investigated by means of HPLC analysis of the intermediates.
Abstract: The degradation of the model pollutant phenol with hydroxyl radicals generated from zero-valent iron and hydrogen peroxide has been investigated by means of HPLC analysis of the intermediates. The optimum conditions for degradation utilise the continuous presence of iron metal, acidic pH and relatively concentrated hydrogen peroxide (9.5 M). When less stringent conditions were used, the products obtained from the decomposition are broadly the same but are formed over a much longer timescale. The intermediates in the oxidation were identified as catechol, hydroquinone, benzoquinone, maleic acid and a relatively stable product, tentatively identified as an organic complex of iron and oxidised catechol.
257 citations
TL;DR: A role for hormesis effects of hydrogen peroxide in promoting longevity is established in Saccharomyces cerevisiae by inducing elevated levels of the reactive oxygen species hydrogenperoxide, which activate superoxide dismutases that inhibit the accumulation of superoxide anions.
Abstract: The free radical theory of aging posits oxidative damage to macromolecules as a primary determinant of lifespan. Recent studies challenge this theory by demonstrating that in some cases, longevity is enhanced by inactivation of oxidative stress defenses or is correlated with increased, rather than decreased reactive oxygen species and oxidative damage. Here we show that, in Saccharomyces cerevisiae, caloric restriction or inactivation of catalases extends chronological lifespan by inducing elevated levels of the reactive oxygen species hydrogen peroxide, which activate superoxide dismutases that inhibit the accumulation of superoxide anions. Increased hydrogen peroxide in catalase-deficient cells extends chronological lifespan despite parallel increases in oxidative damage. These findings establish a role for hormesis effects of hydrogen peroxide in promoting longevity that have broad implications for understanding aging and age-related diseases.
257 citations