Topic
Hydrogen peroxide
About: Hydrogen peroxide is a research topic. Over the lifetime, 42583 publications have been published within this topic receiving 1043732 citations. The topic is also known as: H2O2 & dioxidane.
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TL;DR: It has been found that peroxidase catalyzes the formation of free radicals of hydrogen donors in the presence of H 2 O 2, and Compound III is not an active intermediate for dihydroxyfumarate oxidation.
222 citations
TL;DR: It is shown that, in the presence of hydrogen peroxide, 4-Aminobenzoic acid hydrazide irreversibly inactivates myeloperoxidase, and it is proposed that this inactivation is due to the oxidation of ABAH to a radical that reduces the enzyme to its ferrous intermediate.
Abstract: Hypochlorous acid is the most powerful oxidant generated by neutrophils and is likely to contribute to the damage mediated by these inflammatory cells. The haem enzyme myeloperoxidase catalyses its production from hydrogen peroxide and chloride. 4-Aminobenzoic acid hydrazide (ABAH) is a potent inhibitor of hypochlorous acid production. In this investigation we show that, in the presence of hydrogen peroxide, ABAH irreversibly inactivates myeloperoxidase. ABAH was oxidized by myeloperoxidase, and kinetic analysis of the inactivation conformed to that for a mechanism-based inhibitor. Inactivation was exacerbated by concentrations of hydrogen peroxide greater than 50 microM and by the absence of oxygen. Hydrogen peroxide alone caused minimal inactivation. Reduced glutathione inhibited the oxidation of ABAH as well as the irreversible inhibition of myeloperoxidase. In the presence of oxygen, ABAH and hydrogen peroxide initially converted myeloperoxidase into compound III, which subsequently lost haem absorbance. In the absence of oxygen, the enzyme was converted into ferrous myeloperoxidase and its haem groups were rapidly destroyed. We propose that myeloperoxidase oxidizes ABAH to a radical that reduces the enzyme to its ferrous intermediate. Ferrous myeloperoxidase reacts either with oxygen to allow enzyme turnover, or with hydrogen peroxide to give irreversible inactivation.
221 citations
TL;DR: In this article, it is demonstrated that hydrogen peroxide, electrogenerated at a reticulated vitreous carbon cathode by the reduction of oxygen in the presence of Fe(II) is a powerful oxidant for organic compounds.
221 citations
TL;DR: The results show that modified Fenton's reactions act through a reductive mechanism to degrade compounds that are not reactive with OH*, which broadens the scope of this process for hazardous waste treatment and remediation.
221 citations
TL;DR: The reaction system was modeled as a plug flow reactor in series with a continuous stirred tank reactor (CSTR), and the pseudo-first order rate constant of COD removal was determined from the model based on the experimental data.
220 citations