Showing papers on "Hydroxysteroid dehydrogenase published in 1984"
TL;DR: KI-values for estradiol-17β, progesterone and 20α-dihydroprogesterone were comparable to reported tissue levels of these compounds, consistent with a possible competition in vivo among naturally occurring C18, C19, and C21-steroids for the active site of microsomal 17β-HSD.
24 citations
TL;DR: Rat ovarian 20α-hydroxysteroid dehydrogenase was purified 230-fold with a 48% recovery through a 3-step process involving hydrophobic, gel filtration and gree dye affinity chromatography, indicating a sequential mechanism for the enzyme.
14 citations
TL;DR: In vivo administration of theGF2 fraction in normal cycling female mice also decreased the 3 β-HSD activity in the granulosa cells of the ovarian follicles and plasma progesterone levels indicating the GF2 fraction to be a 3 β -HSD inhibitor.
6 citations
TL;DR: Observations demonstrate that a specific amino acid modification within the enzyme active site was produced by estrone 3-bromoacetate alkylation and suggest that the conformation of the active center was essentially unaltered.
3 citations
2 citations