Topic
Hydroxysteroid dehydrogenase
About: Hydroxysteroid dehydrogenase is a research topic. Over the lifetime, 1087 publications have been published within this topic receiving 28468 citations. The topic is also known as: hydroxysteroid dehydrogenase.
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TL;DR: Targeting signals for different subcellular organelles in human hydroxysteroid dehydrogenases have been identified, however, in several enzymes localization signals remain to be determined.
10 citations
TL;DR: Using quantitative real-time polymerase chain reaction and western blotting analysis, the authors found that sodium butyrate significantly upregulates HSD17B1 long and short transcripts and protein levels in colorectal cancer (CRC) cells.
Abstract: Epidemiological studies have revealed that butyrate and 17β-estradiol (E2) may decrease the incidence of colorectal cancer (CRC). In peripheral tissue, E2 can be produced locally by 17β-hydroxysteroid dehydrogenase 1 (HSD17B1) estrone (E1) reduction. Using quantitative real-time polymerase chain reaction and western blotting analysis, we found that sodium butyrate significantly upregulates HSD17B1 long and short transcripts and protein levels in HT29 and SW707 CRC cells. Chromatin immunoprecipitation analysis showed that upregulation of these transcript levels correlated with an increase in binding of Polymerase II to proximal and distal promoters of HSD17B1. Moreover, we observed that upregulation of HSD17B1 protein levels was associated with increased conversion of E1 to E2 in HT29 and SW707 CRC cells. Since sodium butyrate increases the conversion of E1 to E2, our findings may support the validity of butyrate in the prophylaxis of CRC incidence.
10 citations
TL;DR: In this paper, the synthesis and SAR studies of 3 and 4-substituted 7-hydroxycoumarins as novel 17β-HSD3 inhibitors are discussed.
Abstract: The synthesis and SAR studies of 3- and 4-substituted 7-hydroxycoumarins as novel 17β-HSD3 inhibitors are discussed. The most potent compounds from this series exhibited low nanomolar inhibitory activity with acceptable selectivity versus other 17β-HSD isoenzymes and nuclear receptors.
10 citations
TL;DR: Fibronectin and proteinases in tumor invasion: a review of its structure and biological activity.
Abstract: 'Mancini G, Carbonara AO, Heremans JF. Immunochemical quantitation of antigens by single radialimmunodiffusion. Immunochemistry 1965;2:235-54. 2 Vaheri A, Vartio T, Stenman S, Saksela O, Hedman K, Alitalo K. Fibronectin and proteinases in tumor invasion. In: Strauli P, Barrett AJ, Baici A, eds. Proteinases and tumor invasion. New York: Raven Press, 1980:49-57. Mosesson MW, Amrani DL. Review: the structure and biologic activities of plasma fibronectin. Blood 1980;56:145-58. 4 Mollison PL. Blood transfusion in clinical medicine. 6th ed. Oxford: Blackwell Scientific Publications, 1979. Pearlstein E, Gold LI, Garcia-Pardo A. Fibronectin: a review of its structure and biological activity. Mol Cell Biochem 1980;29:10328.
10 citations
TL;DR: The 3-alpha-hydroxysteroid dehydrogenase and the Pseudomonas testosteroni were purified to homogeneity by polyaerylamide gel electrophoresis and the enzyme was fully inhibited with covalent binding of 1 mole of reagent per mole of subunit suggesting an active site directed inhibition.
10 citations