Topic
Hydroxysteroid dehydrogenase
About: Hydroxysteroid dehydrogenase is a research topic. Over the lifetime, 1087 publications have been published within this topic receiving 28468 citations. The topic is also known as: hydroxysteroid dehydrogenase.
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TL;DR: In this article, the catalytic properties of 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus (17beta-HSDcl) were analyzed by chromatographic, kinetic and thermodynamic means.
10 citations
TL;DR: In this article, the Δ5-3 β-hydroxy steroid dehydrogenase activity and protein content were determined in rats 1 to 24 months of age, and the enzyme activity was maximal at 4 months, but declined to a level in 18-24-month-old rats.
Abstract: SummaryAdrenal Δ5-3 β-hydroxy steroid dehydrogenase activity and protein content were determined in rats 1 to 24 months of age. Activity of the enzyme per milligram of protein declined between 6 and 12 months of age and remained low. Total gland activity was maximal at 4 months of age but declined to a level in 18-24-month-old rats that compared with the 2-month-old animal despite a marked increase in body weight.
9 citations
TL;DR: In this paper, the development of a reliable gram-scale synthesis of 3-{[(16β,17β)-3-(2-bromoethyl)-17-hydroxyestra-1,3,5(10)-trien-16-yl]methylbenzamide (PBRM) was reported.
9 citations
TL;DR: Four forms of this 3(17) alpha-hydroxysteroid dehydrogenase were resolved by a purification procedure which included DEAE-cellulose chromatography and isoelectric focusing and three of the isolated enzymes were homogeneous on the basis of polyacrylamide gel electrophoresis.
9 citations
01 Jan 1980
TL;DR: Oesrer et al. as mentioned in this paper measured the mitochondrial and microsomal fractions of the human term placenta and found that the capability of the Placenta to transform pregnenolone to progesterone was significantly higher after spontaneous vaginal delivery than after elective cesarean section.
Abstract: 5,3{3-hydroxyst~r oid dehydrogenase (.:l 5 ,3,8-HSDH) was measured in the mitochondrial and microsomal fractions of the human term placenta. The capability of the placenta to transform pregnenolone to progesterone was found to b~ significantly higher after spontaneous vaginal delivery than after elective cesarean section (p < 0.001). There Wil-S a significant rise in the placental concentration of estrone occurring at the time of parturition (p < 0.01). The placental concentration of estradioi-17{3 was aiso greater after than beiore parturition but the difference was not statistically significant. Conversely to the estrogen concentration, no difference existed in the progesterone concentration between the two groups of placentas. The significance of these findings is discussed in relation to the parturition process. (AM. J. Oesrer. GYNECOL. 138:500, 1980.)
9 citations