Topic
Hydroxysteroid dehydrogenase
About: Hydroxysteroid dehydrogenase is a research topic. Over the lifetime, 1087 publications have been published within this topic receiving 28468 citations. The topic is also known as: hydroxysteroid dehydrogenase.
Papers published on a yearly basis
Papers
More filters
TL;DR: The results indicate the important role of F217 in the strict NADPH-dependency, as well as its involvement in the unique catalytic properties of AKR1C33.
3 citations
3 citations
TL;DR: In this article, eine Langzeitmedikation mit Indomethacin and Clomiphen erhielten, ergaben eine starkere Hemmung der Enzymaktivitaten als bei einer nur mit Clomikhen behandelten Vergleichsgruppe.
Abstract: Zusammenfassung
Histochemische Untersuchungen der δ5 -3β-Hydroxysteroid-Dehydrogenase und der 17s-Hydroxysteroid-Dehydrogenase im Hoden nach Langzeitgabe von Indomethacin bei Ratten, die mit Clomiphencitrat vorbehandelt wurden
Histochemische Untersuchungen der δ5 -3β-Hydroxysteroid-Dehydrogenase und der 17s-Hydroxysteroid-Dehydrogenase im Hoden prapubertarer Ratten, welche eine Langzeitmedikation mit Indomethacin und Clomiphen erhielten, ergaben eine starkere Hemmung der Enzymaktivitaten als bei einer nur mit Clomiphen behandelten Vergleichsgruppe. Dies last vermuten, das Prostaglandin-Inhibitoren eine direkte Hemmwirkung auf NAD-erfordernde Enzyme ausuben, welche an der Biosynthese von Steroiden im Hoden beteiligt sind.
3 citations
01 Jan 1982
TL;DR: Five beta-Cholanoates, having a hydroxyl group in the 3 alpha and 3 beta and/or 12 alpha and 12 beta configurations, were tested as substrates for two preparation of 3 alpha-hydroxysteroid dehydrogenase (HSDH) and two preparations of 12 alpha-HSDH.
Abstract: 5 beta-Cholanoates, having a hydroxyl group in the 3 alpha and 3 beta and/or 12 alpha and 12 beta configurations, were tested as substrates for two preparation of 3 alpha-hydroxysteroid dehydrogenase (HSDH) and two preparations of 12 alpha-HSDH. When the 3-OH group was in the alpha configuration, both 3 alpha-HSDH preparations reacted, but when it was in the beta configuration, neither 3 alpha-HSDH preparations reacted. This also held true for the 12 alpha-HSDH preparations.
3 citations
TL;DR: Hydroxysteroid dehydrogenase preparation is further improved by rapid purification which facilitates the elimination of protein microheterogeneity, caused in vitro by oxidation, reduction or partial proteolysis, and this leads to even higher efficiency.
3 citations