Topic
Hydroxysteroid dehydrogenase
About: Hydroxysteroid dehydrogenase is a research topic. Over the lifetime, 1087 publications have been published within this topic receiving 28468 citations. The topic is also known as: hydroxysteroid dehydrogenase.
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Patent•
15 May 2018
TL;DR: The 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH) as mentioned in this paper can catalyze asubstrate taurocholic acid to generate taurine 7-ketone cholic acid (T7K-CA), catalyze a substrate GCA to generate GCA, and catalyzes a substrate EB to generate ethyl 2-hydroxyl-2-phenylacetate.
Abstract: The invention discloses 7 alpha-hydroxysteroid dehydrogenase as well as a coding gene and application thereof. An amino acid sequence of the 7 alpha-hydroxysteroid dehydrogenase provided by the invention is shown as SEQ ID NO. 1, and a nucleotide sequence of the 7 alpha-hydroxysteroid dehydrogenase gene is disclosed and shown as SEQ ID NO. 2. The 7 alpha-hydroxysteroid dehydrogenase can catalyze asubstrate taurocholic acid (TCA) to generate taurine 7-ketone cholic acid (T7K-CA), catalyze a substrate glycocholic acid (GCA) to generate glycine 7-ketone cholic acid (G7K-CA), catalyze a substratetaurochenodeoxycholic acid (TCDCA) to generate taurine 7-ketone lithocholic acid (T7K-LCA), catalyze a substrate glycochenodeoxycholic acid (GCDCA) to generate glycine 7-ketone lithocholic acid (G7K-LCA) and catalyze a substrate ethyl benzoylformate (EB) to generate ethyl 2-hydroxy-2-phenylacetate, and has better catalytic activity, has a catalytic activity to TCDCA, GCDCA and EB 10, 5, and 3 times that of sardinia clostridium 7 alpha-HSDH, correspondingly, and has great industrial application value.
3 citations
3 citations
TL;DR: A review on AKR1C3 (aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II), with data on DNA, on the protein encoded, and where the gene is implicated.
Abstract: Review on AKR1C3 (aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)), with data on DNA, on the protein encoded, and where the gene is implicated.
3 citations
Patent•
17 Mar 2006
TL;DR: A skin cosmetic composition is provided to inhibit activity of 3β-hydroxysteroid dehydrogenase and metabolic pathway thereof, thereby decreasing dihydrotestosterone(DHT), which is a final metabolite and being effective for improving sebum metabolism or acne as mentioned in this paper.
Abstract: A skin cosmetic composition is provided to inhibit activity of 3beta-hydroxysteroid dehydrogenase and metabolic pathway thereof, thereby decreasing dihydrotestosterone(DHT), which is a final metabolite and being effective for improving sebum metabolism or acne. The skin cosmetic composition for inhibiting activity of 3beta-hydroxysteroid dehydrogenase comprises 0.001-30 wt.% of at least one selected from the group consisting of epigallocatechingallate(EGCG), gallocatechingallate(GCG), quercetin, kaempferol and myricetin as an effective ingredient.
3 citations
3 citations